Effects of exercise training on oxygen uptake kinetic responses in women with type 2 diabetes
Effects of exercise training on oxygen uptake kinetic responses in women with type 2 diabetes
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DOI：
10.2337/diacare.22.10.1640
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发表时间：
1999-10-01
期刊：
影响因子：
16.2
通讯作者：
Regensteiner, JG
中科院分区：
文献类型：
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作者：
Brandenburg, SL;Reusch, JEB;Regensteiner, JG
目的：与非糖尿病女性相比，无并发症的成熟2型糖尿病女性在运动开始时最大耗氧量（VO2max）降低，摄氧量（VO2）动力学减慢。这些异常不仅出现在最大负荷时，也出现在低水平运动开始时。为了评估未经训练的2型糖尿病患者运动训练可以改善VO2max和VO2动力学的假设，我们测量了绝经前久坐妇女在监督运动训练前后3个月的这些参数。研究设计和方法：共有8名2型糖尿病女性，9名超重的非糖尿病女性和10名苗条的非糖尿病女性被研究。在基线和3个月的运动训练后。受试者接受自行车测力仪测试，获得最大摄氧量和摄氧量动力学数据。结果：在入组时，患有2型糖尿病的女性VO2max最低，VO2动力学最慢。运动训练后，2型糖尿病女性的最大摄氧量（VO2max）比苗条和超重对照组女性提高了28%，分别为5%和8%（糖尿病组与对照组均P < 0.05）。在糖尿病组中，VO2动力学在20和30 W时分别提高了39%和22%。对于对照组，两组的VO2动力学在任何负荷下都没有改善。结论：尽管开始时VO2max最低，VO2动力学最慢，但2型糖尿病患者从运动训练计划中获益比对照组更多。这些发现表明，除了已知的代谢作用外，2型糖尿病患者的运动训练可能是一种有效的治疗方法，可以改善心血管对运动的反应，并通过改善VO2max和VO2动力学来克服低水平的运动损伤。如果在低负荷运动开始时进行循环调节的能力通过运动训练计划得到改善，正如VO2动力学数据所表明的那样，运动对2型糖尿病患者的临床意义是明确的。
OBJECTIVE - Women with uncomplicated ripe 2 diabetes have both a decreased maximal oxygen consumption (VO2max) and slowed oxygen uptake (VO2) kinetics at the onset of exercise compared with nondiabetic women. These abnormalities are seen not only at maximal workloads, but also at the onset of low-level exercise. To evaluate the hypothesis that VO2max and VO2 kinetics would improve with exercise training in untrained people with type 2 diabetes, we measured these parameters in premenopausal sedentary women before and after 3 months of supervised exercise training.RESEARCH DESIGN AND METHODS - A total of 8 women with type 2 diabetes, 9 overweight nondiabetic women, and 10 lean nondiabetic women were studied. At baseline and after 3 months of exercise training. subjects underwent bicycle ergometer testing to obtain VO2max and VO2 kinetics data.RESULTS - On entry, women with type 2 diabetes had the lowest VO2max and slowest VO2 kinetics of the three groups. After exercise training, the women with type 2 diabetes improved their VO2max more than the lean and overweight control women: 28 vs. 5 and 8%, respectively (P < 0.05 for the diabetic group vs. both control groups). In the group with diabetes, VO2 kinetics improved by 39 and 22% at 20 and 30 W, respectively. For the control subjects, VO2 kinetics did not improve at any workload in either group.CONCLUSIONS - Despite beginning with the lowest VO2max and slowest VO2 kinetics, subjects with type 2 diabetes benefited more from an exercise training program than did control subjects. These findings suggest that in addition to its known metabolic effects, exercise training in individuals with type 2 diabetes may be an effective therapy to improve the cardiovascular response to exercise and to overcome low-level exercise impairment as reflected by improved VO2max and VO2 kinetics. If the ability to make circulatory adjustments at the beginning of exercise at low workloads is improved by an exercise training program, as suggested by the VO2 kinetics data, the clinical significance of exercise for people with type 2 diabetes is clear.