Relationships between Rapid Eye Movement Sleep Behavior Disorder and Neurodegenerative Diseases: Clinical Assessments, Biomarkers, and Treatment.
Relationships between Rapid Eye Movement Sleep Behavior Disorder and Neurodegenerative Diseases: Clinical Assessments, Biomarkers, and Treatment.
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快速眼动睡眠行为障碍与神经退行性疾病之间的关系：临床评估、生物标志物和治疗
DOI：
10.4103/0366-6999.229886
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发表时间：
2018-04-20
影响因子：
6.1
通讯作者：
Zhan SQ
中科院分区：
文献类型：
--
作者：
Li M;Wang L;Liu JH;Zhan SQ
快速眼动睡眠行为障碍（RBD）的特征是在快速眼动睡眠期间出现梦境演绎以及肌肉迟缓消失。RBD与α - 突触核蛋白病密切相关，这类疾病包括帕金森病、路易体痴呆和多系统萎缩。许多研究对RBD的影像学、神经生理学、遗传学、认知及自主神经功能标记物，以及它们对神经退行性疾病的预测价值进行了探究。本报告回顾了这些研究的进展，并讨论了其局限性及未来的研究方向。
使用“RBD”“神经退行性疾病”“帕金森病”和“磁共振成像”等组合关键词，在PubMed/MEDLINE数据库中检索截至2018年1月1日的文献。
最初共检索到150篇已发表文章的引用。在这150篇文章中，经过进一步详细审查后选取了92篇。本研究全面参考了所有重要的英文文献。
SCARB2（rs6812193）和MAPT（rs12185268）中的单核苷酸多态性与RBD显著相关。嗅觉丧失、自主神经功能障碍、清醒和快速眼动睡眠期间脑电图明显减慢以及认知障碍，是RBD进展为神经退行性疾病的潜在预测标记物。传统结构成像研究报告的结果相对不一致，而功能成像技术显示左壳核与黑质之间功能连接减少以及多巴胺转运体摄取减少，则是相对一致的研究结果。
应开展更多纵向研究，以评估RBD生物标志物的预测价值。此外，由于葡萄糖和多巴胺代谢并非评估认知的特异性指标，因此应研究与认知直接相关的分子代谢。还需要更多治疗试验，以确定RBD干预措施对预防其进展为神经退行性疾病的有效性。
Rapid eye movement sleep behavior disorder (RBD) is characterized by dream enactment and loss of muscle atonia during rapid eye movement sleep. RBD is closely related to α-synucleinopathies including Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Many studies have investigated the markers of imaging and neurophysiological, genetic, cognitive, autonomic function of RBD and their predictive value for neurodegenerative diseases. This report reviewed the progress of these studies and discussed their limitations and future research directions. Using the combined keywords: “RBD”, “neurodegenerative disease”, “Parkinson disease”, and “magnetic resonance imaging”, the PubMed/MEDLINE literature search was conducted up to January 1, 2018. A total of 150 published articles were initially identified citations. Of the 150 articles, 92 articles were selected after further detailed review. This study referred to all the important English literature in full. Single-nucleotide polymorphisms in SCARB2 (rs6812193) and MAPT (rs12185268) were significantly associated with RBD. The olfactory loss, autonomic dysfunction, marked electroencephalogram slowing during both wakefulness and rapid eye movement sleep, and cognitive impairments were potential predictive markers for RBD conversion to neurodegenerative diseases. Traditional structural imaging studies reported relatively inconsistent results, whereas reduced functional connectivity between the left putamen and substantia nigra and dopamine transporter uptake demonstrated by functional imaging techniques were relatively consistent findings. More longitudinal studies should be conducted to evaluate the predictive value of biomarkers of RBD. Moreover, because the glucose and dopamine metabolisms are not specific for assessing cognitive cognition, the molecular metabolism directly related to cognition should be investigated. There is a need for more treatment trials to determine the effectiveness of interventions of RBD on preventing the conversion to neurodegenerative diseases.