No association between TGFBR 1*6A and lung cancer
No association between TGFBR 1*6A and lung cancer
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DOI：
10.1097/jto.0b013e318070ccd7
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发表时间：
2007-07-01
影响因子：
20.4
通讯作者：
Zhang, Hong-Tao
中科院分区：
文献类型：
--
作者：
You, Weiming;Liu, Zeyi;Zhang, Hong-Tao
简介：TGFBRI *6A 是转化生长因子 β 受体 1 基因 (TGFBRI) 中的一种功能多态性等位基因，据推测会增加各种癌症的风险。然而，关于该变异与肺癌的关系的文献报道很少。方法：为了探索 TGFBRI*6A 是否与肺癌相关，我们对 252 名肺癌患者和 250 名健康对照者进行了基因分型，然后进行了测序。结果：病例中杂合子 9A/6A 的频率为 13.9%，而对照者为 12.4%，比值比为 1. 14 (95%)置信区间：0.68-1.91），不具有统计学意义（p = 0.62），表明TGFBRI*6A不可能是中国肺癌患者的癌症易感因素。结论：我们没有证据支持TGFBRI*64与肺癌相关的假设。
Introduction: TGFBRI *6A, a functionally polymorphic allele in the transforming growth factor beta receptor 1 gene (TGFBRI), has been hypothesized to increase risk of various cancers. However, little has been documented about connection of this variant with lung cancer.Methods: In an attempt to explore whether the TGFBRI*6A is associated with lung cancer, we performed genotyping followed by sequencing in 252 patients with lung cancer and 250 healthy controls.Results: The frequency for the heterozygote 9A/6A is 13.9% in cases compared with 12.4% in controls, and the odds ratio is 1. 14 (95% confidence interval: 0.68-1.91), which is not statistically significant (p = 0.62), suggesting that TGFBRI*6A could not be a cancer susceptibility factor for Chinese patients with lung cancer.Conclusions: We have no evidence to support the hypothesis that TGFBRI*64 is associated with lung cancer.