Worldwide burden of cancer attributable to HPV by site, country and HPV type.
Worldwide burden of cancer attributable to HPV by site, country and HPV type.
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DOI：
10.1002/ijc.30716
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发表时间：
2017-08-15
影响因子：
6.4
通讯作者：
Franceschi S
中科院分区：
文献类型：
--
作者：
de Martel C;Plummer M;Vignat J;Franceschi S
HPV是几乎所有宫颈癌的原因，也是其他肛门生殖器癌和口咽癌的主要原因。了解HPV可归因的癌症负担可以促进HPV疫苗接种和基于HPV的宫颈筛查计划。归因分数（AF）和不同HPV类型的相对贡献来自于已发表的关于癌组织中转化型HPV感染流行率的研究报告。根据GLOBOCAN 2012数据，按国家划分的HPV可归因癌症的年龄标准化发病率地图分别显示了宫颈癌、其他肛门生殖道癌和头颈部癌。还估计了HPV 16/18和HPV 6/11/16/18/31/33/45/52/58的相对贡献。全球4.5%的癌症（每年630，000例新发癌症病例）可归因于HPV：女性8.6%，男性0.8%。女性AF的范围从澳大利亚/新西兰和美国的<3%到印度和撒哈拉以南非洲的>20%。宫颈癌占HPV引起的癌症的83%，其中三分之二发生在欠发达国家。其他HPV引起的肛门生殖器癌包括8，500外阴; 12，000阴道; 35，000肛门（一半发生在男性）和13，000阴茎。在头颈部，HPV引起的癌症代表了38，000例病例，其中21，000例是发生在较发达国家的口咽癌。HPV 16/18和HPV 6/11/16/18/31/33/45/52/58的相对贡献率分别为73%和90%。普及疫苗接种是避免大多数HPV相关癌症病例的关键。HPV 16/18的主要负担和交叉保护的可能性强调了在欠发达国家引入更负担得起的疫苗的重要性。 有什么新消息吗？ 大多数宫颈癌是由人乳头瘤病毒（HPV）感染引起的，因此可以通过筛查和疫苗接种来预防。尽管如此，对HPV归因的癌症预防的努力经常受到获得必要资源的有限性的破坏。目前的研究估计，全世界多达4.5%的新发癌症病例，包括宫颈癌、肛门生殖道癌和头颈癌，与HPV感染有关。仅宫颈癌就占这些病例的83%，其中大部分影响欠发达国家的妇女。研究结果强调了HPV筛查和疫苗接种的重要性以及对成本较低的疫苗的需求。
HPV is the cause of almost all cervical cancer and is responsible for a substantial fraction of other anogenital cancers and oropharyngeal cancers. Understanding the HPV‐attributable cancer burden can boost programs of HPV vaccination and HPV‐based cervical screening. Attributable fractions (AFs) and the relative contributions of different HPV types were derived from published studies reporting on the prevalence of transforming HPV infection in cancer tissue. Maps of age‐standardized incidence rates of HPV‐attributable cancers by country from GLOBOCAN 2012 data are shown separately for the cervix, other anogenital tract and head and neck cancers. The relative contribution of HPV16/18 and HPV6/11/16/18/31/33/45/52/58 was also estimated. 4.5% of all cancers worldwide (630,000 new cancer cases per year) are attributable to HPV: 8.6% in women and 0.8% in men. AF in women ranges from <3% in Australia/New Zealand and the USA to >20% in India and sub‐Saharan Africa. Cervix accounts for 83% of HPV‐attributable cancer, two‐thirds of which occur in less developed countries. Other HPV‐attributable anogenital cancer includes 8,500 vulva; 12,000 vagina; 35,000 anus (half occurring in men) and 13,000 penis. In the head and neck, HPV‐attributable cancers represent 38,000 cases of which 21,000 are oropharyngeal cancers occurring in more developed countries. The relative contributions of HPV16/18 and HPV6/11/16/18/31/33/45/52/58 are 73% and 90%, respectively. Universal access to vaccination is the key to avoiding most cases of HPV‐attributable cancer. The preponderant burden of HPV16/18 and the possibility of cross‐protection emphasize the importance of the introduction of more affordable vaccines in less developed countries. What's new? Most cervical cancers result from human papillomavirus (HPV) infection and therefore are preventable through screening and vaccination. Nonetheless, efforts toward HPV‐attributable cancer prevention frequently are undermined by limited access to necessary resources. The present study estimates that worldwide as many as 4.5% of new cancer cases, including cancers of the cervix, anogenital tract and head and neck, are associated with HPV infection. Cervical cancer alone accounts for 83% of those cases, most of which affect women in less‐developed countries. The findings emphasize the importance of HPV screening and vaccination and the need for less‐costly vaccines.
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DOI：
10.1097/qad.0000000000000808
发表时间：
2015-10-23
期刊：
AIDS (London, England)
影响因子：
--
作者：
de Martel C;Shiels MS;Franceschi S;Simard EP;Vignat J;Hall HI;Engels EA;Plummer M
通讯作者：
Plummer M
影响因子：
78.8
作者：
Xavier Bosch, F.;Robles, Claudia;Cuzick, Jack
通讯作者：
Cuzick, Jack
影响因子：
51.1
作者：
Kreimer, Aimee R.;Struyf, Frank;Del Rosario-Raymundo, Mora Rowena;Hildeshim, Allan;Skinner, S. Rachel;Wacholder, Sholom;Garland, Suzanne M.;Herrero, Rolando;David, Marfe-Pierre;Mfeeler, Cosette M.
通讯作者：
Mfeeler, Cosette M.
影响因子：
6.4
作者：
Guan, Peng;Howell-Jones, Rebecca;Clifford, Gary M.
通讯作者：
Clifford, Gary M.
影响因子：
64.8
作者：
Cancer Genome Atlas Research Network;Albert Einstein College of Medicine;Analytical Biological Services;Barretos Cancer Hospital;Baylor College of Medicine;Beckman Research Institute of City of Hope;Buck Institute for Research on Aging;Canada's Michael Smith Genome Sciences Centre;Harvard Medical School;Helen F. Graham Cancer Center &Research Institute at Christiana Care Health Services;HudsonAlpha Institute for Biotechnology;ILSbio, LLC;Indiana University School of Medicine;Institute of Human Virology;Institute for Systems Biology;International Genomics Consortium;Leidos Biomedical;Massachusetts General Hospital;McDonnell Genome Institute at Washington University;Medical College of Wisconsin;Medical University of South Carolina;Memorial Sloan Kettering Cancer Center;Montefiore Medical Center;NantOmics;National Cancer Institute;National Hospital, Abuja, Nigeria;National Human Genome Research Institute;National Institute of Environmental Health Sciences;National Institute on Deafness &Other Communication Disorders;Ontario Tumour Bank, London Health Sciences Centre;Ontario Tumour Bank, Ontario Institute for Cancer Research;Ontario Tumour Bank, The Ottawa Hospital;Oregon Health &Science University;Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center;SRA International;St Joseph's Candler Health System;Eli &Edythe L. Broad Institute of Massachusetts Institute of Technology &Harvard University;Research Institute at Nationwide Children's Hospital;Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University;University of Bergen;University of Texas MD Anderson Cancer Center;University of Abuja Teaching Hospital;University of Alabama at Birmingham;University of California, Irvine;University of California Santa Cruz;University of Kansas Medical Center;University of Lausanne;University of New Mexico Health Sciences Center;University of North Carolina at Chapel Hill;University of Oklahoma Health Sciences Center;University of Pittsburgh;University of São Paulo, Ribeir ão Preto Medical School;University of Southern California;University of Washington;University of Wisconsin School of Medicine &Public Health;Van Andel Research Institute;Washington University in St Louis
通讯作者：
Washington University in St Louis