Pneumococcal microbial surface components recognizing adhesive matrix molecules targeting of the extracellular matrix.
Pneumococcal microbial surface components recognizing adhesive matrix molecules targeting of the extracellular matrix.
复制标题
识别靶向细胞外基质的粘附基质分子的肺炎球菌表面成分。
DOI：
10.1111/j.1365-2958.2010.07190.x
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发表时间：
2010-07-01
影响因子：
3.6
通讯作者：
Orihuela CJ
中科院分区：
文献类型：
--
作者：
Paterson GK;Orihuela CJ
The attachment of bacteria to host cells and tissues and their subsequent invasion and dissemination are key processes during disease pathogenesis. In this issue of Molecular Microbiology, Jensch and co-workers provide further molecular insight into these events during infection with the Gram-positive bacterium Streptococcus pneumoniae. Their characterization of PavB, a bacterial surface protein with orthologues in other streptococci, shows it to bind the extracellar matrix components fibronection and plasminogen by virtue of repetitive sequences designated Streptococcal Surface Repeats (SSURE). In mice, a pavB mutant showed reduced nasopharyngeal colonisation and was attenuated in a lung infection model. As discussed here in the context of the pneumococcus, the study of PavB highlights the central role during microbal pathogenesis of targetting the extracellular matrix by so-called MSCRAMMs (microbial surface components recognizing adhesive matrix molecules).
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影响因子：
3.1
作者：
Michelin, E.;Snijders, D.;Barbato, A.
通讯作者：
Barbato, A.
影响因子：
5.8
作者：
Carneiro, CRW;Postol, E;Brentani, RR
通讯作者：
Brentani, RR
影响因子：
6.7
作者：
Hilleringmann M;Giusti F;Baudner BC;Masignani V;Covacci A;Rappuoli R;Barocchi MA;Ferlenghi I
通讯作者：
Ferlenghi I
影响因子：
3.6
作者：
Bergmann, S;Wild, D;Hammerschmidt, S
通讯作者：
Hammerschmidt, S
影响因子：
3.8
作者：
Anderton, Julie M.;Rajam, Gowrisankar;Ades, Edwin W.
通讯作者：
Ades, Edwin W.