FIBER PATHWAYS OF BASAL FOREBRAIN CHOLINERGIC NEURONS IN MONKEYS
FIBER PATHWAYS OF BASAL FOREBRAIN CHOLINERGIC NEURONS IN MONKEYS
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DOI：
10.1016/0006-8993(87)90783-9
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发表时间：
1987-03-17
期刊：
影响因子：
2.9
通讯作者：
PRICE, DL
中科院分区：
文献类型：
--
作者：
KITT, CA;MITCHELL, SJ;PRICE, DL
在恒河猴中，放射自显影示踪方法，辅以免疫细胞化学和组织化学技术，被用来描绘的途径，Meynert基底核（nbM）和Broca斜角带核（ndBB）的胆碱能神经元项目前脑的目标。将[~ 3 H]氨基酸注入这些核团后，发现了5条主要的纤维通路：nbM和ndBB的轴突主要在扣带回束内向内侧投射到半球的背内侧部分：nbM和ndBB纤维在苍白球和纹状体下方横向引出，进入外囊和极囊，并在放射冠内终止于新皮质的外侧和尾侧区域;从nbM向腹侧行进的轴突投射到颞叶的部分，包括杏仁核;一些纤维穿过眶额纤维到达眶额皮质;最后，nbM/ndBB的轴突经由海马伞/穹窿和腹侧通路投射到海马。乙酰胆碱酯酶组织化学和胆碱乙酰转移酶免疫细胞化学证实了基底前脑胆碱能神经元产生的这5个放射性标记途径的存在。
In rhesus monkeys, autoradiographic tracing methods, complemented by immunocytochemical and histochemical techniques, were used to delineate pathways by which cholinergic neurons of the nucleus basalis of Meynert (nbM) and nucleus of the diagonal band of Broca (ndbB) project to forebrain targets. Following injections of [3H]amino acids into these nuclei, 5 major fiber pathways were identified: axons of the nbM and ndbB project medially, principally within the cingulum bundle, to dorsomedial portions of the hemispheres: nbM an ndbB fibers exit laterally beneath the pallidum and striatum, enter the external and extreme capsules, and pass within the corona radiata to terminate in lateral and caudal regions of neocortex; axons coursing ventrally from the nbM project to portions of the temporal lobe, including the amygdala; some fibers pass through the fibrae orbitofrontales to the orbitofrontal cortex; and, finally, axons of the nbM/ndbB project via the fimbria/fornix and a ventral pathway to the hippocampus. The presence of these 5 radiolabeled pathways arising from basal forebrain cholinergic neurons was confirmed by acetylcholinesterase histochemistry and choline acetyltransferase immunocytochemistry.