On-line high-precision carbon position-specific stable isotope analysis: A review
On-line high-precision carbon position-specific stable isotope analysis: A review
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DOI：
10.1016/j.trac.2015.07.010
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发表时间：
2016-02
期刊：
影响因子：
--
通讯作者：
C. Gauchotte-Lindsay;S. Turnbull
中科院分区：
文献类型：
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作者：
C. Gauchotte-Lindsay;S. Turnbull
自1990年气相色谱仪与燃烧炉和同位素比质谱联用首次商业化以来，有机分子的化合物特异性稳定同位素分析一直是广泛研究领域科学突破的起源。然而，非反应原子的存在可以掩盖分子稳定同位素特征的变化;位置特异性同位素分析（PSIA）是对超分子同位素变化的研究。在简要考虑了同位素研究这一新水平的潜力和前景后，在这项研究中，我们回顾了一些现有的定制系统在线PSIA使用连续流同位素比质谱仪器和研究人员如何解决与这项技术有关的问题。分子碎片化过程中观察到的和优化的各种分子也讨论了在线PSIA，因为它将提供信息，其应用到新的化合物。
Since the first commercial availability of gas chromatographs coupled with a combustion furnace and an isotope ratio mass spectrometry in 1990, compound-specific stable isotope analysis of organic molecules has been at the origin of scientific breakthroughs in a wide range of research fields. The presence of non-reacting atoms, however, can mask changes in molecular stable isotopic signatures; position-specific isotope analysis (PSIA) is the study ofintramolecular isotopic variations. After a brief consideration of the potential and prospect of this new level in isotopic studies, in this study, we review few existing custom-built systems for on-line PSIA using continuous flow isotope ratio mass spectrometry instrumentation and how researchers have addressed issues related to this technique. Molecular fragmentation processes observed and optimised for various molecules are also discussed for on-line PSIA, as it would provide information on their application to new compounds.