Modern Synthetic Avenues for the Preparation of Functional Fluorophores.
Modern Synthetic Avenues for the Preparation of Functional Fluorophores.
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DOI：
10.1002/anie.201609394
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发表时间：
2017-03-27
期刊：
影响因子：
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通讯作者：
Vendrell M
中科院分区：
文献类型：
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作者：
de Moliner F;Kielland N;Lavilla R;Vendrell M
生物医学研究依赖于以非侵入性方式快速准确地分析特定生物分子和细胞。功能性荧光团是这类研究的有力工具。由于这些复杂的结构通常难以通过传统的合成策略获得，因此在过去的几年里，新的化学工艺得到了发展。在这篇综述中，我们描述了通过多组分反应、C - H活化过程、环加成和基于生物分子的化学转化，在荧光团的设计、制备和微调方面的最新进展。
Biomedical research relies on the fast and accurate profiling of specific biomolecules and cells in a non‐invasive manner. Functional fluorophores are powerful tools for such studies. As these sophisticated structures are often difficult to access through conventional synthetic strategies, new chemical processes have been developed in the past few years. In this Minireview, we describe the most recent advances in the design, preparation, and fine‐tuning of fluorophores by means of multicomponent reactions, C−H activation processes, cycloadditions, and biomolecule‐based chemical transformations.