Moderate wine consumption in the prevention of metabolic syndrome and its related medical complications
Moderate wine consumption in the prevention of metabolic syndrome and its related medical complications
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DOI：
10.2174/187153008784534385
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发表时间：
2008-06-01
影响因子：
1.9
通讯作者：
Xu, Aimin
中科院分区：
文献类型：
--
作者：
Liu, Ling;Wang, Yu;Xu, Aimin
代谢综合征（MetS）包括与发展2型糖尿病和心血管疾病（CVD）的高风险相关的一系列心脏代谢异常，心血管疾病是老龄化人口中的头号杀手。最近的研究表明，适度饮酒对预防代谢综合征及其相关并发症的发展具有多种有益作用。适度饮酒与代谢综合征和动脉粥样硬化性心脏病的发病率较低之间的关系在许多针对不同种族群体的流行病学研究中得到了反复证实。除了适度的乙醇摄入对脂质分布的有利影响外，富含于红葡萄酒中的多酚通过其抗氧化、抗炎、血管保护和胰岛素增敏特性对MetS具有超越酒精的多重益处。在这些红葡萄酒多聚体化合物中值得注意的是白藜芦醇，这是一种植物抗毒素，由于其在模拟卡路里限制中的作用，最近引起了极大的关注。该化合物可以作为NAD（+）依赖性脱乙酰酶sirtuins的有效激活剂，以延长寿命并防止过量摄入对胰岛素抵抗和代谢紊乱的有害影响。此外，白藜芦醇通过刺激AMP激活的蛋白激酶和促进线粒体生物合成发挥其对MetS的多重保护作用。在这篇综述中，我们强调了最近的流行病学和实验证据支持适度的葡萄酒摄入量对代谢综合征及其相关的心脏代谢并发症的保护作用，并讨论了红葡萄酒多酚的多重有益作用的分子机制，重点是白藜芦醇。
The metabolic syndrome (MetS) encompasses a constellation of cardio-metabolic abnormalities associated with a high risk of developing type 2 diabetes and cardiovascular disease (CVD), the top killer in the ageing population. Recent studies have demonstrated multiple beneficial effects of moderate wine consumption in the protection against development of the MetS and its related medical complications. The association of moderate wine consumption with lower incidence of the MetS and atherosclerotic heart disease has been repeatedly documented in numerous epidemiological studies on diverse ethnic groups. In addition to the favorable effects of moderate ethanol intake on lipid profiles, polyphenols enriched in red wine possess multiple benefits on the MetS beyond alcohol through their anti-oxidant, anti-inflammatory, vascular-protective and insulin-sensitizing properties. Notable among these red wine polypheolic compounds is resveratrol, a phytoalexin that has recently attracted great attention due to its role in mimicking calorie restriction. This compound can act as a potent activator of the NAD(+)-dependent deacetylases sirtuins to expand the life span and to prevent the deleterious effects of excess intake on insulin resistance and metabolic derangement. In addition, resveratrol exerts its multiple protective effects against the MetS through stimulating AMP-activated protein kinase and promoting mitochondria biogenesis. In this review, we highlight the recent epidemiological and experimental evidences supporting the protective effects of moderate wine intake against the MetS and its associated cardio-metabolic complications, and discuss the molecular mechanisms underlying the multiple beneficial actions of red wine polyphenols with the focus on resveratrol.