Testisimmune privilege - Assumptions versus facts.
Testisimmune privilege - Assumptions versus facts.
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DOI：
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发表时间：
2013
影响因子：
1.7
通讯作者：
Gurvinder Kaur;P. Mital;J. Dufour
中科院分区：
文献类型：
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作者：
Gurvinder Kaur;P. Mital;J. Dufour
长期以来，睾丸一直享有免疫特权部位的声誉，这是基于其保护自身抗原性生殖细胞的能力，并为移植的同种或异种移植物的延长存活提供最佳环境。睾丸免疫赦免的解剖学，生理学，免疫学和细胞成分的作用的探索表明，睾丸的致耐受性环境是由睾丸细胞（主要是支持细胞，管周肌样细胞，间质细胞和常驻巨噬细胞）表达或分泌的免疫调节因子的结果。血睾屏障/支持细胞屏障对隔离晚期生殖细胞也很重要，但其在睾丸免疫赦免中的作用需要进一步研究。睾丸免疫豁免不是永久性的，因为有效的免疫应答可以针对移植的组织进行，并且睾丸中的细菌/病毒感染可以有效地消除。总的来说，细胞成分控制免疫应答的命运，并且可以将应答从免疫破坏性转变为免疫保护性，从而导致免疫赦免。
The testis has long enjoyed a reputation as an immunologically privileged site based on its ability to protect auto-antigenic germ cells and provide an optimal environment for the extended survival of transplanted allo- or xeno-grafts. Exploration of the role of anatomical, physiological, immunological and cellular components in testis immune privilege revealed that the tolerogenic environment of the testis is a result of the immunomodulatory factors expressed or secreted by testicular cells (mainly Sertoli cells, peritubular myoid cells, Leydig cells, and resident macrophages). The blood-testis barrier/Sertoli cell barrier, is also important to seclude advanced germ cells but its requirement in testis immune privilege needs further investigation. Testicular immune privilege is not permanent, as an effective immune response can be mounted against transplanted tissue, and bacterial/viral infections in the testis can be effectively eliminated. Overall, the cellular components control the fate of the immune response and can shift the response from immunodestructive to immunoprotective, resulting in immune privilege.