URINARY-EXCRETION OF LIGNANS AND ISOFLAVONOID PHYTOESTROGENS IN JAPANESE MEN AND WOMEN CONSUMING A TRADITIONAL JAPANESE DIET
URINARY-EXCRETION OF LIGNANS AND ISOFLAVONOID PHYTOESTROGENS IN JAPANESE MEN AND WOMEN CONSUMING A TRADITIONAL JAPANESE DIET
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DOI：
10.1093/ajcn/54.6.1093
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发表时间：
1991-12-01
影响因子：
7.1
通讯作者：
OKADA, H
中科院分区：
文献类型：
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作者：
ADLERCREUTZ, H;HONJO, H;OKADA, H
流行病学研究表明，在日本妇女和男子消费传统的饮食依赖癌症的死亡率低。我们以前发现，某些双酚类食物成分，木脂素和多酚，这是由肠道微生物菌群转化为生物活性的类物质，可能是癌症的保护剂。因此，我们研究了这些化合物（肠内酯，肠二醇，大豆苷元，雌马酚，O-去甲基安哥林素）的尿排泄在10名妇女和9名男子在日本京都南部的农村。受试者食用典型的低脂肪饮食，包括大量的大米和豆制品、鱼和蔬菜。同位素稀释气相色谱-质谱法用于测定。尿中木脂素的排泄量很低，但木脂素的排泄量很高。大豆制品的摄入量相关的排泄。日本女性和男性的乳腺癌和前列腺癌死亡率分别较低，可能是由于大豆产品的高摄入量。
Epidemiologic studies revealed low mortality in hormone-dependent cancer in Japanese women and men consuming a traditional diet. We previously found that certain diphenolic food components, lignans and isoflavonoids, which are converted to biologically active hormone-like substances by intestinal microflora, may be cancer-protective agents. Therefore, we studied urinary excretion of these compounds (enterolactone, enterodiol, daidzein, equol, and O-desmethylangolensin) in 10 women and 9 men in a rural village south of Kyoto, Japan. The subjects consumed a typical low-fat diet with much rice and soy products, fish, and vegetables. An isotope-dilution gas chromatographic-mass spectrometric method was used for the assays. The urinary excretion of lignans was low but that of the isoflavonoids was very high. The excretion of isoflavonoids correlated with soybean-product intake. The low mortality in breast and prostate cancer of Japanese women and men, respectively, may be due to the high intake of soybean products.