Investigating the impact of spatial priors on the performance of model-based IVUS elastography.

Investigating the impact of spatial priors on the performance of model-based IVUS elastography.
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DOI:
10.1088/0031-9155/56/22/014
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发表时间:
2011-11-21
影响因子:
3.5
通讯作者:
Doyley MM
Doyley MM
中科院分区:
工程技术2区
文献类型:
--
作者:
Richards MS;Doyley MM

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This paper describes methods that provide pre-requisite information for computing circumferential stress in modulus elastograms recovered from vascular tissue—information that could help cardiologists detect life-threatening plaques and predict their propensity to rupture. The modulus recovery process is an ill-posed problem; therefore additional information is needed to provide useful elastograms. In this work, prior geometrical information was used to impose hard or soft constraints on the reconstruction process. We conducted simulation and phantom studies to evaluate and compare modulus elastograms computed with soft and hard constraints versus those computed without any prior information. The results revealed that (1) the contrast-to-noise ratio of modulus elastograms achieved using the soft prior and hard prior reconstruction methods exceeded those computed without any prior information; (2) the soft prior and hard prior reconstruction methods could tolerate up to 8 % measurement noise; and (3) the performance of soft and hard prior modulus elastogram degraded when incomplete spatial priors were employed. This work demonstrates that including spatial priors in the reconstruction process should improve the performance of model-based elastography, and the soft prior approach should enhance the robustness of the reconstruction process to errors in the geometrical information.
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