Higher serum phenylalanine concentration is associated with more rapid telomere shortening in men
Higher serum phenylalanine concentration is associated with more rapid telomere shortening in men
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DOI：
10.3945/ajcn.116.130468
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发表时间：
2017-01-01
影响因子：
7.1
通讯作者：
Salonen, Minna K.
中科院分区：
文献类型：
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作者：
Eriksson, Johan G.;Guzzardi, Maria-Angela;Salonen, Minna K.
背景：端粒长度和端粒缩短与年龄相关的健康结果有关。只有少数研究已经能够纵向报道的因素，是与端粒长度的变化在老龄化population.Objective：我们研究了端粒长度之间的纵向关系，端粒长度的变化，和循环氨基酸。设计：来自赫尔辛基出生队列研究的共812例受试者（出生于1934年至1944年），在10年的时间间隔内进行了3次临床访视，包括心脏代谢危险因素的测量，被纳入研究。白细胞端粒长度（LTL）的测量与使用定量实时聚合酶链反应。循环支链和芳香族氨基酸（丙氨酸，甘氨酸，组氨酸，苯丙氨酸，亮氨酸，异亮氨酸，缬氨酸和酪氨酸）进行了评估与使用高通量nuclear magnetic resonance spectroscopic.Results：在平均年龄为71岁的男性和女性的相对+/- SD LTL分别为0.79 +/- 0.27和0.89 +/- 0.35（P < 0.001）。在研究的氨基酸中，观察到5年前测定的苯丙氨酸浓度与LTL之间存在最强的负相关性。这一发现在男性中具有显著性（P = 0.021），在多重比较调整后仍具有显著性，但在女性中不具有显著性（P = 0.39）。纵向上，在LTL超过10年的变化呈负相关的苯丙氨酸浓度在男性（P = 0.007），但不是在女性（P = 0.58）调整后的基线LTL，年龄，吸烟，和身体脂肪的百分比。结论：血清苯丙氨酸浓度与端粒长度，因此，可能与老化过程。由于报告的相关性是观察性的，因此无法得出因果关系的结论。我们的研究结果支持这样的假设，即调节衰老的细胞途径是性别特异性的。
Background: Telomere length and telomere shortening are associated with age-related health outcomes. Only a few studies have been able to longitudinally report on factors that are associated with changes in telomere length in an aging population.Objective: We studied the longitudinal relation between telomere length, the change in telomere length, and circulating amino acids.Design: A total of 812 subjects from the Helsinki Birth Cohort Study (born from 1934 to 1944), who underwent 3 clinical visits during a 10-y interval that included measurements of cardiometabolic risk factors, were included in the study. Leukocyte telomere length (LTL) was measured with the use of quantitative real-time polymerase chain reaction. Circulating branched-chain and aromatic amino acids (alanine, glycine, histidine, phenylalanine, leucine, isoleucine, valine, and tyrosine) were assessed with the use of high-throughput nuclear magnetic resonance spectroscopy.Results: The relative +/- SD LTL at a mean age of 71 y was 0.79 +/- 0.27 in men and 0.89 +/- 0.35 in women (P < 0.001). Of the studied amino acids, the strongest inverse association was observed between the phenylalanine concentration that was measured 5 y earlier and the LTL. This finding was significant in men (P = 0.021) and remained significant after adjustment for multiple comparisons, but it was not significant in women (P = 0.39). Longitudinally, the change in LTL over 10 y was inversely associated with the phenylalanine concentration in men (P = 0.007) but not in women (P = 0.58) after adjustment for baseline LTL, age, smoking, and percentage of body fat.Conclusions: The serum phenylalanine concentration is associated with telomere length and, therefore, potentially with the aging process. Because the associations reported are observational, no conclusions can be made regarding causality. Our findings support the hypothesis that cellular pathways that regulate aging are sex specific.