Does locomotive syndrome severity predict future fragility fractures in community-dwelling women with osteoporosis?
Does locomotive syndrome severity predict future fragility fractures in community-dwelling women with osteoporosis?
复制标题
运动综合征的严重程度是否可以预测患有骨质疏松症的社区女性未来的脆性骨折？
DOI：
10.1093/mr/roac101
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发表时间：
2022
影响因子：
2.2
通讯作者：
Asano Satoshi
中科院分区：
文献类型：
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作者：
Asahi Ryoma;Nakamura Yutaka;Koike Yoshinao;Kanai Masayoshi;Watanabe Kento;Yuguchi Satoshi;Kamo Tomohiko;Azami Masato;Ogihara Hirofumi;Asano Satoshi
目的探讨机车综合征（LS）的严重程度是否会影响骨质疏松患者未来的脆性骨折。方法对315例骨质疏松症女性患者（平均随访2.8年）进行回顾性队列研究，其中244例纳入分析。在基线时，我们获得了医疗信息、腰椎和股骨颈的骨密度以及矢状垂直轴。此外，使用两步测试、站立测试和25题老年机车功能量表评分来评估LS风险。LS风险测试结果用于对LS严重程度进行分类，从0级（稳健）到3级（恶化），分为4个等级。采用Cox比例风险回归分析来确定严重程度与未来脆性骨折的关系。结果315例患者中37例发生脆性骨折，占11.8%。本研究显示矢状垂直轴（风险比= 1.014,95%可信区间1.005 ~ 1.023，p值= 0.003）和LS严重程度（风险比=1.748,95%可信区间1.133 ~ 2.699,p= 0.012）是易碎性骨折发生的独立危险因素。结论LS严重程度可作为脆性骨折的预测指标。我们认为，与骨质疏松症相关的LS进展增加了骨折的风险。
ObjectivesWe investigated whether the locomotive syndrome (LS) severity affects future fragility fractures in osteoporosis patients.MethodsIn this retrospective cohort study, 315 women with osteoporosis (mean follow-up period, 2.8 years) were reviewed, of whom 244 were included in the analysis. At baseline, we obtained medical information, bone mineral density of the lumbar spine and femoral neck, and sagittal vertical axis. Additionally, LS risk was assessed using the two-step test, stand-up test, and 25-question geriatric locomotive function scale scores. The LS risk test results were used to classify LS severity, which was rated on a 4-point scale from stage 0 (robust) to 3 (worsening). Cox proportional hazards regression analysis was used to determine the association of the severity with future fragility fracture.ResultsFragility fractures occurred in 37 of 315 participants (11.8%). This study showed that sagittal vertical axis (hazard ratio = 1.014; 95% confidence interval, 1.005–1.023;pvalue = 0.003) and LS severity (hazard ratio =1.748; 95% confidence interval, 1.133–2.699;p= 0.012) were independent risk factors for incidence of fragility fracture.ConclusionsThis study revealed the LS severity to predicted fragility fractures. We suggested that the progression of LS associated with osteoporosis increases the fracture risk.