Systemic and Mucosal Immune Responses to Cryptosporidium-Vaccine Development.
Systemic and Mucosal Immune Responses to Cryptosporidium-Vaccine Development.
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DOI：
10.1007/s40475-015-0054-y
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发表时间：
2015-09-01
影响因子：
5.4
通讯作者：
Ward HD
中科院分区：
文献类型：
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作者：
Ludington JG;Ward HD
隐孢子虫属是全世界腹泻病的主要原因，特别是在发展中国家的营养不良儿童和未经治疗的艾滋病患者中，隐孢子虫可导致严重、慢性和使人衰弱的疾病。不幸的是，对于这些易感人群没有持续有效的药物，也没有疫苗，部分原因是对寄生虫和宿主免疫反应的了解有限。在这篇综述中，我们将讨论目前对隐孢子虫感染的全身和粘膜免疫反应的理解，讨论开发隐孢子虫疫苗的可行性，并评估隐孢子虫疫苗开发策略的最新进展
Cryptosporidium spp is a major cause of diarrheal disease worldwide, particularly in malnourished children and untreated AIDS patients in developing countries in whom it can cause severe, chronic and debilitating disease. Unfortunately, there is no consistently effective drug for these vulnerable populations and no vaccine, partly due to a limited understanding of both the parasite and the host immune response. In this review, we will discuss our current understanding of the systemic and mucosal immune responses to Cryptosporidium infection, discuss the feasibility of developing a Cryptosporidium vaccine and evaluate recent advances in Cryptosporidium vaccine development strategies