Beneficial effects of long-chain n-3 fatty acids included in an energy-restricted diet on insulin resistance in overweight and obese European young adults
Beneficial effects of long-chain n-3 fatty acids included in an energy-restricted diet on insulin resistance in overweight and obese European young adults
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DOI：
10.1007/s00125-008-1035-7
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发表时间：
2008-07-01
期刊：
影响因子：
8.2
通讯作者：
Thorsdottir, I.
中科院分区：
文献类型：
--
作者：
Ramel, A.;Martinez, A.;Thorsdottir, I.
目的/假设流行病学研究表明，长链n-3多不饱和脂肪酸（LC n-3 PUFA）可改善胰岛素抵抗。本研究的目的是调查在能量限制期间，海鲜消费对超重参与者胰岛素抵抗的影响。方法在为期8周的饮食干预中，324名参与者（20-40岁，BMI 25.5 -32.5 kg/m(2)，来自冰岛、西班牙和爱尔兰）被计算机随机分配到四种能量限制饮食（-30E%）中的一种，这些饮食具有相同的宏量营养素组成，但不同的LC n-3 PUFA含量：对照组（n = 80，不含海鲜，单盲）；瘦肉鱼（n=80；鳕鱼150克，每周3次）；多脂鱼（84条；鲑鱼150克，每周3次）；(4)鱼油（n=80；每日二十二碳六烯酸/二十碳五烯酸胶囊，不含其他海产品；单盲）。在基线和终点分别测定空腹血糖、胰岛素、脂联素、血浆甘油三酯和红细胞膜脂肪酸。使用胰岛素抵抗稳态模型评估（HOMA-IR）计算胰岛素抵抗。采用固定效应和协变量的线性模型，研究了与对照组相比，海鲜消费对空腹胰岛素和HOMA-IR的影响。结果278名参与者（86%）完成了干预。鱼油摄入量是8周后空腹胰岛素和胰岛素抵抗的重要预测因子，即使在统计分析中将体重减轻、甘油三酯减少、膜中LC n-3 PUFA增加或脂联素变化作为协变量后，这一发现仍然显著。体重减轻也是病情改善的重要预测指标。结论/解释能量减少过程中LC n-3 PUFA的消耗对年轻超重个体的胰岛素抵抗有积极影响，独立于体重、甘油三酯、红细胞膜或脂联素的变化。试验注册：ClinicalTrials.gov NCT00315770。资助：YOUNG研究是SEAFOODplus综合项目的一部分，该项目由欧盟委员会通过第6号框架计划合同资助。食品- ct - 2004 - 506359。
Aims/hypothesis Epidemiological research indicates that long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) improve insulin resistance. The aim of this study was to investigate the effects of seafood consumption on insulin resistance in overweight participants during energy restriction.Methods In this 8 week dietary intervention, 324 participants (20-40 years, BMI 27.5-32.5 kg/m(2), from Iceland, Spain and Ireland) were randomised by computer to one of four energy-restricted diets (-30E%) of identical macronutrient composition but different LC n-3 PUFA content: control (n = 80; no seafood; single-blinded); lean fish (n=80; 150 g cod, three times/week); fatty fish (n=84; 150 g salmon, three times/week); (4) fish oil (n=80; daily docosahexaenoic/eicosapentaenoic acid capsules, no other seafood; single-blinded). Fasting glucose, insulin, adiponectin, plasma triacylglycerol and fatty acids in erythrocyte membrane were measured at baseline and endpoint. Insulin resistance was calculated using the homeostasis model assessment of insulin resistance (HOMA-IR). Linear models with fixed effects and covariates were used to investigate the effects of seafood consumption on fasting insulin and HOMA-IR at endpoint in comparison with the control group.Results Of the participants, 278 (86%) completed the intervention. Fish oil intake was a significant predictor of fasting insulin and insulin resistance after 8 weeks, and this finding remained significant even after including weight loss, triacylglycerol reduction, increased LC n-3 PUFA in membranes or adiponectin changes as covariates in the statistical analysis. Weight loss was also a significant predictor of improvements.Conclusions/interpretation LC n-3 PUFA consumption during energy reduction exerts positive effects on insulin resistance in young overweight individuals, independently from changes in body weight, triacylglycerol, erythrocyte membrane or adiponectin.Trial registration: ClinicalTrials.gov NCT00315770.Funding: The YOUNG study is part of the SEAFOODplus Integrated Project, which is funded by the EC through the 6th Framework Programme Contract No. FOOD-CT-2004-506359.