REGULATION OF BONE-FORMATION .2.
REGULATION OF BONE-FORMATION .2.
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DOI：
10.1056/nejm198307143090206
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发表时间：
1983-01-01
影响因子：
158.5
通讯作者：
KREAM, BE
中科院分区：
文献类型：
--
作者：
RAISZ, LG;KREAM, BE
糖皮质激素糖皮质激素对钙调节和骨代谢具有复杂的作用。临床上，糖皮质激素过量会导致骨骼生长受损和骨量减少。25然而，糖皮质激素似乎在调节骨生长方面具有生理作用。糖皮质激素过量会减少肠道对钙和磷酸盐的吸收，并增加其肾脏排泄。这些影响可能会导致继发性甲状旁腺功能亢进，并可能会导致骨软化症。然而，与糖皮质激素相关的骨质减少被称为骨质疏松症，因为矿化没有明显的缺陷。这可能是因为糖皮质激素也会抑制新基质的形成，从而使宽的类骨质接缝不形成。 。 。
GlucocorticoidsGlucocorticoids have complex effects on calcium regulation and bone metabolism. Clinically, glucocorticoid excess causes impaired skeletal growth and decreased bone mass.25Yet it seems likely that glucocorticoids have a physiologic role in regulating bone growth. Glucocorticoid excess decreases the intestinal absorption of calcium and phosphate and increases their renal excretion. These effects can produce secondary hyperparathyroidism and might be expected to produce osteomalacia. However, the osteopenia associated with glucocorticoids is termed osteoporosis because there is no obvious defect in mineralization. This may be because glucocorticoids also inhibit the formation of new matrix, so that wide osteoid seams do not . . .