Metabolic Activation of Xenobiotics: Ethylene Dibromide and Structural Analogs
Metabolic Activation of Xenobiotics: Ethylene Dibromide and Structural Analogs
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异生素的代谢激活：二溴乙烯和结构类似物
DOI：
10.3109/10915818309140692
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发表时间：
1983
影响因子：
2.2
通讯作者：
P. J. Bladeren
中科院分区：
文献类型：
--
作者：
P. J. Bladeren
大量可以进入生物体的化合物本身是相对无害的，但会被人体转化为反应性试剂。这种化合物的结构是决定其在生物体中的分布的因素。它的理化特性决定了其吸收、分布和排泄的整体命运，而化学结构是其生物转化的决定性因素。活性中间体的形成是否发生取决于它对不同的酶系统有什么攻击点。细胞大分子被活性中间体烷基化的程度取决于特定细胞中激活和解毒酶的平衡，以及中间体对细胞大分子中关键靶点的反应。许多化学物质经历几个并行的代谢途径。这些途径之间的比例可能是一个决定性的因素，决定了不良反应的程度。
A large number of compounds which can enter living organisms are relatively harmless as such, but are transformed by the body into reactive agents. The structure of such a compound is the factor determining its disposition in the organism. Its physicochemical characteristics determine the overall fate in terms of absorption, distribution and excretion, while the chemical structure is the decisive factor in its biotransformation. Whether formation of reactive intermediates occurs depends on what points of attack it has to offer to the different enzyme systems. The extent to which alkylation of cellular macromolecules by reactive intermediates occurs in turn depends on the balance of activating and detoxifying enzymes in the particular cell and on the reactivity of the intermediates towards critical targets in the cell macro-molecules.Many chemicals undergo several concurrent metabolic pathways. The ratio between these pathways may be a decisive factor determining the extent of adverse effects caused by the...
影响因子：
3.8
作者：
GUENGERICH, FP;CRAWFORD, WM;WATANABE, PG
通讯作者：
WATANABE, PG