Association of BMI with the β3-adrenergic receptor gene polymorphism in Japanese:: Meta-analysis
Association of BMI with the β3-adrenergic receptor gene polymorphism in Japanese:: Meta-analysis
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DOI：
10.1038/oby.2001.102
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发表时间：
2001-12-01
期刊：
影响因子：
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通讯作者：
Satoh, H
中科院分区：
文献类型：
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作者：
Kurokawa, N;Nakai, K;Satoh, H
目的：为了评估β 3-肾上腺素能受体基因（ADRB 3）中Trp 64 Arg多态性对日本人体重指数（BMI）的影响，我们选择了一些研究，这些研究使用MEDLINE和PubMed评估了日本人BMI和ADRB 3多态性之间的关联。数据收集后，进行扩展方差分析以评估不同基因型的差异。结果：在总共35个亚组中，包括2316名携带Trp 64 Arg变体的受试者和4266名不携带该变体的受试者，BMI的加权平均差异为0.26 kg/m（2）（95%可信区间：0.18 ~ 0.42; p < 0.01），表明变异携带者的BMI比正常纯合子受试者高。虽然已知ADRB 3多态性的等位基因频率在种族之间不同，但本研究主要针对日本人群，其ADRB 3多态性等位基因频率较高。我们假设由于受试者数量充足，可以防止统计错误。总之。结果支持ADRB 3基因多态性与BMI相关的假设。
Objective: To assess the effect of the Trp64Arg polymorphism in the beta3-adrenergic receptor gene (ADRB3) on body mass index (BMI) in the Japanese population.Research Methods and Procedures: We selected studies that evaluated the association between BMI and ADRB3 polymorphism among Japanese, using MEDLINE and PubMed. After data collection, an extension of ANOVA was performed to assess the differences according to the genotype.Results: In a total of 35 subgroups including 2316 subjects with the Trp64Arg variant and 4266 subjects without this variant, the weighted mean difference in BMI was 0.26 kg/m(2) (95% confidence interval: 0.18 to 0.42; p < 0.01), indicating that variant carriers exhibited higher BMI than did normal homozygous subjects.Discussion: Although it is known that the allele frequency of the ADRB3 polymorphism differs among races, this study focuses on the Japanese population, which has a high allele frequency of ADRB3 polymorphism. We assumed that statistical errors would be prevented due to the sufficient number of subjects. In conclusion. the results support the hypothesis that ADRB3 gene polymorphism is associated with BMI.