Sensitisation, asthma, and a modified Th2 response in children exposed to cat allergen: a population-based cross-sectional study
Sensitisation, asthma, and a modified Th2 response in children exposed to cat allergen: a population-based cross-sectional study
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DOI：
10.1016/s0140-6736(00)04168-4
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发表时间：
2001-03-10
期刊：
影响因子：
168.9
通讯作者：
Sporik, R
中科院分区：
文献类型：
--
作者：
Platts-Mills, T;Vaughan, J;Sporik, R
尽管哮喘与室内过敏原的速发型超敏反应密切相关，但一些研究表明，家中的猫可以降低哮喘的风险。我们调查了对猫和螨过敏原的免疫应答，以及广泛接触过敏原的儿童的哮喘。（12-14岁），其中一些人有哮喘和支气管高反应性的症状，通过同种型测量的螨（Der f 1）和猫（Fel d 1）过敏原抗体（IgG和IgG 4）特异性放射免疫沉淀分析与室内灰尘中的致敏性和过敏原浓度进行比较。其中47人有哮喘和支气管高反应性症状，螨暴露增加与过敏和Der f 1 IgG抗体的患病率增加有关。相比之下，猫的最高暴露量与致敏性降低相关，但Fel d 1 IgG抗体的患病率较高。因此，在高暴露量的儿童中，对螨而非猫致敏的几率为4.0（99% CI 1.49-10.00）。此外。在76名家中有23 μ g Fel d 1的儿童中，有31名对猫过敏原不敏感，其Fel d 1 IgG抗体>125单位。在过敏性和非过敏性儿童中，IgG 4同种型的Fel d 1抗体与IgG抗体强烈相关（分别为r=0.84和r=0.66）。对螨或猫过敏原致敏是哮喘最强的独立危险因素（p
Background Although asthma is strongly associated with immediate hypersensitivity to indoor allergens, several studies have suggested that a cat in the house can decrease the risk of asthma. We investigated the immune response to cat and mite allergens, and asthma among children with a wide range of allergen exposure.Methods We did a population-based cross-sectional study of children (aged 12-14 years), some of whom had symptoms of asthma and bronchial hyper-reactivity, Antibodies to mite (Der f 1) and cat (Fel d 1) allergens measured by isotype (IgG and IgG4) specific radioimmunoprecipitation assays were compared with sensitisation and allergen concentrations in house dust.Findings 226 children were recruited, 47 of whom had symptoms of asthma and bronchial hyper-reactivity, Increasing exposure to mite was associated with increased prevalence of sensitisation and IgG antibody to Der f 1. By contrast, the highest exposure to cat was associated with decreased sensitisation, but a higher prevalence of IgG antibody to Fel d 1, Thus, among children with high exposure, the odds of sensitisation to mite rather than cat was 4.0 (99% CI 1.49-10.00). Furthermore. 31 of 76 children with 23 mug Fel d 1 at home, who were not sensitised to cat allergen had >125 units of IgG antibody to Fel d 1. Antibodies to Fel d 1 of the IgG4 isotype were strongly correlated with IgG antibody in both allergic and non-allergic children (r=0.84 and r=0.66, respectively). Sensitisation to mite or cat allergens was the strongest independent risk factor for asthma (p