The use of amnestic and nonamnestic composite measures at different thresholds in the neuropsychological diagnosis of MCI.
The use of amnestic and nonamnestic composite measures at different thresholds in the neuropsychological diagnosis of MCI.
复制标题
在 MCI 的神经心理学诊断中使用不同阈值的遗忘和非遗忘复合测量。
DOI：
10.1080/13803390600681206
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发表时间：
2007
影响因子：
2.2
通讯作者：
Duara,Ranjan
中科院分区：
文献类型：
--
作者：
Loewenstein,DavidA;Acevedo,Amarilis;Agron,Joscelyn;Martinez,Glenda;Duara,Ranjan
在轻度认知障碍（MCI）患者中观察到遗忘和非遗忘缺陷。大多数研究都集中在单一认知测试的损伤上，而不是合并多种测量结果来得出复合损伤指数。在这项调查中，我们检查了 20 名被诊断为前驱阿尔茨海默病 AD 的 MCI 患者（平均简易精神状态检查，MMSE = 26.1；SD= 1.7），并根据 1.5-SD 和 2.0-SD 损伤临界值的综合测量，确定了他们与 70 名正常老年对照的区别程度。在 1.5-SD 临界值时，MCI-AD 组中记忆指数受损的中位数为 7 个中的 5 个，而在 2.0-SD 临界值时，中位数为 7 个中的 4 个。在 1.5-SD 临界值和 2.0-SD 临界值时，中位数为 7 个中的 3 个和 7 个非记忆指数中的 2 个受损。接受者操作者特征（ROC）分析表明，2.0SD 时记忆测试受损的总数（敏感性 = 95.0%/特异性 = =84.3%）以及记忆受损和非记忆测量的综合测量（敏感性85.0%/特异性100%）具有高水平的辨别力，并且可能具有作为早期损伤以及MCI严重程度的指标的实用性。
Both amnestic and nonamnestic deficits have been observed in patients with mild cognitive impairment (MCI). Most studies have focused on impairment on single cognitive tests rather than amalgamation of the results of several measures to arrive at a composite impairment index. In this investigation, we examined 20 MCI patients diagnosed as prodromal Alzheimer's disease, AD (mean Mini-Mental State Examination, MMSE = 26.1;SD= 1.7) and determined the extent to which they could be differentiated from 70 normal elderly controls based on composite measures at 1.5-SDand 2.0-SDcutoffs for impairment. At the 1.5-SDcutoff, the median number of memory indices impaired in the MCI-AD group was 5 of 7, whereas at the 2.0-SDcutoff, the median number was 4 of 7. A median of 3 of 7 and 2 of 7 nonmemory indices were impaired at 1.5- and 2.0-SDcutoffs for impairment. Receiver operator characteristics (ROC) analyses indicated that the total number of memory tests impaired at 2.0SD(sensitivity = 95.0%/specificity = 84.3%) and the composite measure of both impaired memory and nonmemory measures (sensitivity of 85.0%/specificity of 100%) had high levels of discrimination and may have utility as indices of early impairment as well as severity of MCI.