The plasma B-type natriuretic peptide levels are low in males with stable ischemic heart disease (IHD) compared to those observed in patients with non-IHD: a retrospective study.
The plasma B-type natriuretic peptide levels are low in males with stable ischemic heart disease (IHD) compared to those observed in patients with non-IHD: a retrospective study.
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DOI：
10.1371/journal.pone.0108983
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Yoshimura M
中科院分区：
文献类型：
--
作者：
Minai K;Ogawa T;Kawai M;Komukai K;Tanaka T;Ogawa K;Nagoshi T;Arase S;Morimoto S;Inoue Y;Sekiyama H;Urabe A;Matsuo S;Hongo K;Yoshimura M
虽然血浆B型利钠肽（BNP）水平是心力衰竭的标志物，但BNP本身是否在缺血性心脏病（IHD）的发病机制中起关键作用尚不清楚。在这项研究中，我们回顾性地检测了稳定型IHD患者的血浆BNP水平，并与稳定型心血管疾病患者进行了比较。研究人群为2088例患者（1698例男性和390例女性），他们因IHD（n = 1，661）和非IHD（n = 427）入院并接受了心导管插入术。 进行血液动力学参数的测量和血液采样。IHD组血浆BNP水平明显低于非IHD组（P<0.001）。对logBNP值进行的多元回归分析显示，年龄、男性、低左心室射血分数、低体重指数、血清肌酐、房颤和IHD本身是显著的解释变量。当总研究人群按性别划分时，发现男性IHD组的血浆BNP水平显著低于非IHD组（p<0.001），但女性则无此差异（p = NS）。 此外，IHD的多元逻辑回归分析显示，logBNP值是男性的显著解释变量（回归系数：-0.669，p<0.001），但不是女性（p = NS）。 与稳定的非IHD患者相比，稳定的IHD患者的血浆BNP水平相对较低;这种趋势在男性中很明显。BNP的低反应性可能与男性IHD有因果关系。我们希望这项研究将作为未来前瞻性研究的一个测试。
Although the plasma B-type natriuretic peptide (BNP) level is a marker of heart failure, it is unclear whether BNP per se plays a pivotal role for pathogenic mechanisms underlying the development of ischemic heart disease (IHD). In this study, we retrospectively examined the plasma BNP levels in stable patients with IHD and compared to stable patients with cardiovascular diseases other than IHD. The study population was 2088 patients (1698 males and 390 females) who were admitted to our hospital due to IHD (n = 1,661) and non-IHD (n = 427) and underwent cardiac catheterization. Measurements of the hemodynamic parameters and blood sampling were performed. The plasma BNP levels were significantly lower in the IHD group than in the non-IHD group (p<0.001). The multiple regression analysis examining the logBNP values showed that age, a male gender, low left ventricular ejection fraction, low body mass index, serum creatinine, atrial fibrillation and IHD per se were significant explanatory variables. When the total study population was divided according to gender, the plasma BNP levels were found to be significantly lower in the IHD group than in the non-IHD group among males (p<0.001), but not females (p = NS). Furthermore, a multiple logistic regression analysis of IHD showed the logBNP value to be a significant explanatory variable in males (regression coefficient: −0.669, p<0.001), but not females (p = NS). The plasma BNP levels were relatively low in stable patients with IHD compared with those observed in stable patients with non-IHD; this tendency was evident in males. Perhaps, the low reactivity of BNP is causally associated with IHD in males. We hope that this study will serve as a test of future prospective studies.
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影响因子：
37.8
作者：
Omland, T;Aakvaag, A;Dickstein, K
通讯作者：
Dickstein, K
影响因子：
5.8
作者：
FERRARI, P;WEIDMANN, P;SHAW, S
通讯作者：
SHAW, S
影响因子：
24
作者：
Macheret, Fima;Boerrigter, Guido;Burnett, John C., Jr.
通讯作者：
Burnett, John C., Jr.
DOI：
10.1073/pnas.0508782102
发表时间：
2005-11-29
影响因子：
11.1
作者：
Hawkridge, AM;Heublein, DM;Muddiman, DC
通讯作者：
Muddiman, DC
影响因子：
15.9
作者：
MUKOYAMA, M;NAKAO, K;IMURA, H
通讯作者：
IMURA, H