The Association Between Dietary Intake and Phenotypical Characteristics of COPD in the ECLIPSE Cohort
The Association Between Dietary Intake and Phenotypical Characteristics of COPD in the ECLIPSE Cohort
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DOI：
10.15326/jcopdf.1.1.2014.0113
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发表时间：
2014-05-01
影响因子：
2.4
通讯作者：
Rennard, Stephen
中科院分区：
文献类型：
--
作者：
Hanson, Corrine;Sayles, Harlan;Rennard, Stephen
背景资料：饮食是一个潜在的可改变的危险因素，在许多疾病的发展和进展，有证据表明，饮食在COPD中发挥作用。目的：评价饮食摄入量和COPD的临床特征之间的关系，在一个大的和良好的特征人群的COPD患者和对照谁是ECLIPSE研究的一部分。方法：在3年的时间里，2,167名参与者在8个时间点获得了有限的饮食记录。参与者报告了他们在过去24小时内对8种食物的消费量。每个食物组的摄入量作为二分变量处理（8个随访时间点中任何一个时间点的是/最后24小时vs.所有8个时间点的否）。然后在最后一次随访时使用临床结局指标对这两组进行比较，包括肺功能、肺气肿、6分钟步行、圣乔治呼吸系统量表（SGRQ）评分、3年内这些评分的变化以及炎症生物标志物。对每个食物组和每个结果测量运行多变量模型，以调整年龄、性别、体重指数（BMI）和吸烟等混杂因素。最近食用与健康饮食相关的食物（包括鱼、水果、茶和乳制品）的参与者的肺功能指标更高，随着时间的推移下降更少，肺气肿和肺气肿进展更少，6分钟步行和SGRQ评分更高，某些炎症标志物水平更低。增加饮食记录的时间点，包括在分析中提高检测显着associations.Conclusion：饮食作为一个可能的可改变的危险因素在COPD继续值得调查的能力。
Background: Diet is a potentially modifiable risk factor in the development and progression of many diseases, and there is evidence that diet plays a role in COPD.Objective: Evaluate the relationship between dietary intake and clinical characteristics of COPD in a large and well-characterized population of COPD patients and controls who were part of the ECLIPSE study.Methods: Limited diet records were available from 2,167 participants at 8 time points over a 3-year period. Participants reported the amount they had consumed over the last 24 hours for 8 food categories. Intake of each food group was handled as a dichotomous variable (Yes/last 24 hours at any of the 8 follow-up points vs. No at all 8 points). These 2 groups were then compared using clinical outcome measures at the last available follow-up that included lung function, emphysema, 6-minute walk, St. George's Respiratory Questionaire (SGRQ) scores, the change in these scores over a 3-year period, and inflammatory biomarkers. Multivariate models for each food group and each outcome measure were run to adjust for confounding factors of age, sex, body mass index (BMI), and smoking.Results: Participants who demonstrated recent consumption of foods associated with a healthful diet, including fish, fruit, tea, and dairy products, had greater lung function measures and less decline over time, less emphysema and emphysema progression, greater 6-minute walk and SGRQ scores, and lower levels of certain inflammatory markers. Increasing the number of diet record time points that were included in the analysis improved ability to detect significant associations.Conclusion: Diet as a possible modifiable risk factor in COPD continues to warrant investigation.