Cloning and molecular evolution of the aldehyde dehydrogenase 2 gene (Aldh2) in bats (Chiroptera).
Cloning and molecular evolution of the aldehyde dehydrogenase 2 gene (Aldh2) in bats (Chiroptera).
复制标题
蝙蝠（翼手目）乙醛脱氢酶 2 基因 (Aldh2) 的克隆和分子进化。
DOI：
10.1007/s10528-012-9540-2
复制
发表时间：
2013
影响因子：
2.4
通讯作者：
Chen Y
中科院分区：
文献类型：
--
作者：
Chen Y
Old World fruit bats (Pteropodidae) and New World fruit bats (Phyllostomidae) ingest significant quantities of ethanol while foraging. Mitochondrial aldehyde dehydrogenase (ALDH2, encoded by theAldh2gene) plays an important role in ethanol metabolism. To test whether theAldh2gene has undergone adaptive evolution in frugivorous and nectarivorous bats in relation to ethanol elimination, we sequenced part of the coding region of the gene (1,143 bp, ~73 % coverage) in 14 bat species, including three Old World fruit bats and two New World fruit bats. Our results showed that theAldh2coding sequences are highly conserved across all bat species we examined, and no evidence of positive selection was detected in the ancestral branches leading to Old World fruit bats and New World fruit bats. Further research is needed to determine whether other genes involved in ethanol metabolism have been the targets of positive selection in frugivorous and nectarivorous bats.
