Role of OCT2 and MATE1 in renal disposition and toxicity of nitidine chloride

Role of OCT2 and MATE1 in renal disposition and toxicity of nitidine chloride
复制标题

OCT2 和 MATE1 在氯化两面针的肾脏处置和毒性中的作用

DOI:
10.1111/bph.13537
复制
发表时间:
2016-08-01
影响因子:
7.3
通讯作者:
Jiang, H. D.
Jiang, H. D.
中科院分区:
医学2区
文献类型:
--
作者:
Li, L. P.;Song, F. F.;Jiang, H. D.

文献摘要

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氯化尼替丁(Nitidine chloride, NC)是一种苯并苯胺类生物碱,具有抗癌、镇痛等多种生物学特性。本研究的目的是评估有机阳离子转运蛋白2 (OCT2)和多药和毒素挤出1 (MATE1)在NC肾配置和肾毒性中的作用。
Nitidine chloride (NC), a benzophenanthridine alkaloid, has various biological properties including anticancer and analgesic activities. The aim of the present study was to evaluate the role of organic cation transporter 2 (OCT2) and multidrug and toxin extrusion 1 (MATE1) in the renal disposition and nephrotoxicity of NC.