Uncovering the Role of RNA-Binding Proteins in Gene Expression in the Immune System.
Uncovering the Role of RNA-Binding Proteins in Gene Expression in the Immune System.
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DOI：
10.3389/fimmu.2018.01094
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发表时间：
2018
影响因子：
7.3
通讯作者：
Turner M
中科院分区：
文献类型：
--
作者：
Díaz-Muñoz MD;Turner M
Fighting external pathogens requires an ever-changing immune system that relies on tight regulation of gene expression. Transcriptional control is the first step to build efficient responses while preventing immunodeficiencies and autoimmunity. Post-transcriptional regulation of RNA editing, location, stability, and translation are the other key steps for final gene expression, and they are all controlled by RNA-binding proteins (RBPs). Nowadays we have a deep understanding of how transcription factors control the immune system but recent evidences suggest that post-transcriptional regulation by RBPs is equally important for both development and activation of immune responses. Here, we review current knowledge about how post-transcriptional control by RBPs shapes our immune system and discuss the perspective of RBPs being the key players of a hidden immune cell epitranscriptome.
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