Insane in the Membrane: Glial Extracellular Vesicles Transmit Polyomaviruses.
Insane in the Membrane: Glial Extracellular Vesicles Transmit Polyomaviruses.
复制标题
膜中的疯狂：胶质细胞外囊泡传播多瘤病毒。
DOI：
10.1128/mbio.01024-19
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发表时间：
2019
期刊：
影响因子：
6.4
通讯作者：
Altan-Bonnet,Nihal
中科院分区：
文献类型：
--
作者：
Santiana,Marianita;Altan-Bonnet,Nihal
细胞外小泡(EVS)是在宿主间运输病毒区块的主要载体。虽然RNA病毒构成了EVS传播的绝大多数，但在最近发表在mBio(mBio 10：e00379-19,2019年)上的一篇文章中，https://mbio.asm.org/content/10/2/e00379-19.long)，Morris-Love及其同事透露，一种双链DNA(DsDNA)病毒JC多瘤病毒(JCPyV)是EV中进行性多灶性白质脑病的主要原因，它可以从EV中的其他胶质细胞释放并传播到其他胶质细胞。这种传播方式似乎具有很高的传染性，不依赖于游离的病毒附着和进入受体LSTc和5-HT2，并且不受中和抗体的保护。这种新的JCPyV传播形式可能潜在地解释了它传播到中枢神经系统(CNS)和其毒力增加的原因。
Extracellular vesicles (EVs) are major vehicles for transporting virusesen blocamong hosts. While RNA viruses make up the great majority of transmission by EVs, in a recent article inmBio(mBio 10:e00379-19, 2019, https://mbio.asm.org/content/10/2/e00379-19.long), Morris-Love and colleagues revealed that a double-stranded DNA (dsDNA) virus, JC polyomavirus (JCPyV), a major cause of progressive multifocal leukoencephalopathy (PML), can be released from and transmitted to other glia in EVs. This mode of transmission appears to be highly infectious, independent of the free virus attachment and entry receptors LSTc and 5-HT2, and protected from neutralizing antibodies. This novel form of JCPyV transmission may potentially explain its dissemination into the central nervous system (CNS) and its increased virulence.