Genetic variation in 8q24 associated with risk of colorectal cancer
Genetic variation in 8q24 associated with risk of colorectal cancer
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DOI：
10.4161/cbt.6.7.4704
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发表时间：
2007-07-01
影响因子：
3.6
通讯作者：
Rennert, Gad
中科院分区：
文献类型：
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作者：
Gruber, Stephen B.;Moreno, Victor;Rennert, Gad
染色体8q24含有已知参与结直肠癌发病机制的癌基因，以及最近被证明影响前列腺癌遗传风险的未知基因变异。在以色列北部一项基于人群的结直肠癌病例对照研究中，我们调查了8q24基因变异与结直肠癌风险之间的关系。在年龄、性别、种族和临床相匹配的1,861个发病病例和1,937个基于人群的对照中，10505477卢比与结直肠癌的风险在优势模型中相关，优势比=1.23，95%可信区间=1.05-1.43，(p=0.008)。这种关联在风险等位基因携带者亲属的癌症分析中得到了独立验证，风险比为3.2(95%自举CI=1.16-17.8)。位于8q24上的rS 10505477的遗传变异可能会导致该人群中14%的结直肠癌，应该在其他研究中复制。
Chromosome 8q24 harbors oncogenes known to be involved in pathogenesis of colorectal cancer (CRC) as well as uncharacterized genetic variants that have recently been shown to influence inherited risk of prostate cancer. In a population-based case-control study of colorectal cancer in northern Israel, we investigated the association between variation in 8q24 and risk of CRC. Among 1,861 incident cases and 1,937 population-based controls matched on age, gender, ethnicity, and clinic, rs 10505477 was associated with risk of CRC in a dominant model, with an odds ratio = 1.23, 95% confidence interval = 1.05-1.43, (p = 0.008). This association was independently validated in an analysis of cancer among relatives of carriers of the risk allele, with a hazard ratio of 3.2 (95% bootstrap CI = 1.16-17.8). Genetic variation at rs 10505477 on 8q24 potentially accounts for 14% of CRC in this population and should be replicated in other studies.