Antiinflammatory activity of coumarins from Santolina oblongifolia
Antiinflammatory activity of coumarins from Santolina oblongifolia
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DOI：
10.1021/np960422f
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发表时间：
1996-12-01
影响因子：
5.1
通讯作者：
Villar, A
中科院分区：
文献类型：
--
作者：
Silvan, AM;Abad, MJ;Villar, A
从长圆叶山椒（Santolina oblongifolia Boiss）的乙酸乙酯萃取物中分离得到4个香豆素类化合物。（菊科）。它们被鉴定为7-甲氧基香豆素（herniarin）（1）、6，7-二羟基香豆素（aescuoke）（2）、6-甲氧基-7-葡糖基香豆素（scopolin）（3）和6-羟基-7-甲氧基香豆素（scopoletin）（4）。这是首次从Santolina属植物中分离到秦皮甲素和东莨菪碱。分离的香豆素显示出显着的活性作为类花生酸释放的抑制剂从离子载体刺激的小鼠腹腔巨噬细胞。
Four coumarins were isolated from the EtOAc extract of the flower-tops of Santolina oblongifolia Boiss. (Compositae). They were identified as 7-methoxycoumarin (herniarin) (1), 6,7-dihydroxycoumarin (aesculetin) (2), 6-methoxy-7-glucosidylcoumarin (scopolin) (3), and 6-hydroxy-7-methoxycoumarin (scopoletin) (4). This is the first report of the isolation of aesculetin and scopolin from the genus Santolina. The isolated coumarins showed marked activity as inhibitors of eicosanoid-release from ionophore-stimulated mouse peritoneal macrophages.