ONTOGENETIC DEVELOPMENT OF KAINATE NEUROTOXICITY - CORRELATES WITH GLUTAMATERGIC INNERVATION
ONTOGENETIC DEVELOPMENT OF KAINATE NEUROTOXICITY - CORRELATES WITH GLUTAMATERGIC INNERVATION
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DOI：
10.1073/pnas.75.4.2025
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发表时间：
1978-01-01
影响因子：
11.1
通讯作者：
COYLE, JT
中科院分区：
文献类型：
--
作者：
CAMPOCHIARO, P;COYLE, JT
Stereotaxic injection of kainic acid into the striatum of adult rats causes degeneration of neurons intrinsic to the striatum but spares axons of passage and of termination of extrinsic neurons. Neurochemical and histologic studies demonstrate that striatal neurons are almost insensitive to kainate at 7 days after birth and that their vulnerability increases with age; by 3 wk after birth, striatal injection of kainate produces a lesion comparable to that of the adult. The intensity and duration of the acute behavioral response to kainate also increases with age. The maturational increase in striatal neuronal sensitivity to kainate correlates with the development of glutamatergic innervation to the striatum, as measured by [3H]glutamate uptake by synaptosomes, and with the development of a postsynaptic, high-affinity receptor site for kainate. These ontogenetic studies provide additional evidence that kainate''s neurotoxicity is a receptor-mediated event related to glutamatergic innervation of vulnerable neurons.
