Evaluation of plasma resistant hollow fiber membranes for artificial lungs
Evaluation of plasma resistant hollow fiber membranes for artificial lungs
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DOI：
10.1097/01.mat.0000138078.04558.fe
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发表时间：
2004-09-01
期刊：
影响因子：
4.2
通讯作者：
Federspiel, WJ
中科院分区：
文献类型：
--
作者：
Eash, HJ;Jones, HM;Federspiel, WJ
用于人工肺（充氧器）的中空纤维膜（HFMs）会发生血浆渗漏（或湿润），血浆缓慢地填充纤维壁的孔隙，血浆渗漏到气体通道中，整体气体交换减少。为了克服这个问题，人们正在开发抗等离子体纤维，这些纤维是微孔氧合纤维的非对称或复合对称版本。本报告评估了几种候选的抗等离子体HFMs的气体渗透性和等离子体阻力，通过表面活性剂湿化测试测量。将五种候选纤维相互比较，并与一种对照纤维进行比较。与控制纤维的1.62E-02和1.77E-02相比，抗等离子纤维的CO2和O-2气体渗透率（单位为ml/s/cm(2)/cm Hg）分别为3.15E-04至1.71 E-03和3.400 e -04至1.08E-03。在强制湿出测试中，抗等离子纤维的最大染料渗出率明显低于对照纤维。抗等离子纤维的CO2气体渗透性对人工肺设计施加了最大的限制，以实现充分的气体交换。然而，我们的研究结果表明，在广泛的人工肺应用中，使用特殊的蒙皮和复合HFMs可以获得足够的血浆阻力，同时保持可接受的二氧化碳气体渗透率。
Hollow fiber membranes (HFMs) used in artificial lungs (oxygenators) undergo plasma leakage (or wetting) in which blood plasma slowly fills the pores of the fiber wall, plasma leaks into gas pathways, and overall gas exchange decreases. To overcome this problem plasma resistant fibers are being developed that are skinned asymmetric or composite symmetric versions of microporous oxygenator fibers. This report evaluates several candidate plasma resistant HFMs in terms of their gas permeance and plasma resistance as measured in a surfactant wet out test. Five candidate fibers were compared with each other and with a control fiber. CO2 and O-2 gas permeance (in ml/s/cm(2)/cm Hg) in the plasma resistant fibers ranged from 3.15E-04 to 1.71 E-03 and 3.40E-04 to 1.08E-03, respectively, compared with 1.62E-02 and 1.77E-02 for the control fiber. Maximum dye bleed through for the plasma resistant fibers in the forced wet out test were significantly less than for the control fiber. CO2 gas permeance of a plasma resistant fiber imposes the greatest constraint upon artificial lung design for sufficient gas exchange. However, our results suggest sufficient plasma resistance can be achieved using special skinned and composite HFMs while maintaining an acceptable CO2 gas permeance for a broad range of artificial lung applications.