Epigenetic changes in pediatric solid tumors: promising new targets.
Epigenetic changes in pediatric solid tumors: promising new targets.
复制标题
小儿实体瘤的表观遗传变化：有希望的新靶标。
DOI：
10.1158/1078-0432.ccr-11-1921
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发表时间：
2012-05-15
期刊：
影响因子：
--
通讯作者：
Thiele CJ
中科院分区：
文献类型：
--
作者：
Lawlor ER;Thiele CJ
癌症正在根据最近的发现重新解释，这些发现与组蛋白密码和发育过程中基因程序的表观遗传调控和控制的动态性质有关，以及从整个癌症基因组测序中获得的见解。体细胞突变或染色质修饰酶的表达失调正在以高频率被鉴定。这在儿科胚胎性实体瘤中最为相关，其中出现了一幅图片，显示与这些肿瘤相关的经典遗传改变最终集中在表观基因组上，以失调发育程序。在这篇综述中，我们涉及如何改变的转录机制和染色质修饰基因的组成部分有助于儿童实体瘤的发生和发展。我们还将讨论我们对癌症表观遗传失调的基本机制的理解如何取得巨大进展，为靶向癌症治疗提供新的途径。
Cancer is being re-interpreted in light of recent discoveries related to the histone code and the dynamic nature of epigenetic regulation and control of gene programs during development, as well as insights gained from whole cancer genome sequencing. Somatic mutations or deregulated expression of chromatin modifying enzymes are being identified at high frequency. Nowhere is this more relevant than in pediatric embryonal solid tumors wherein a picture is emerging which shows that classic genetic alterations associated with these tumors ultimately converge on the epigenome to dysregulate developmental programs. In this review we relate how alterations in components of the transcriptional machinery and chromatin modifier genes contribute to the initiation and progression of pediatric solid tumors. We also will discuss how dramatic progress in our understanding of the fundamental mechanisms that contribute to epigenetic deregulation in cancer is providing novel avenues for targeted cancer therapy.