Effects of tubulin assembly inhibitors on cell division in prokaryotes in vivo
Effects of tubulin assembly inhibitors on cell division in prokaryotes in vivo
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DOI：
10.1016/s0378-1097(00)00365-7
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发表时间：
2000-10-01
影响因子：
2.1
通讯作者：
Mullineaux, CW
中科院分区：
文献类型：
--
作者：
Sarcina, M;Mullineaux, CW
细菌细胞分裂蛋白FtsZ是微管蛋白的结构类似物。FtsZ基因失活的细菌突变株不能分裂。已知许多微管蛋白组装的抑制剂：其中一些用作杀菌剂。FtsZ和微管蛋白之间结构上的高度同源性增加了其中一些抑制物可能影响细菌细胞分裂的可能性。在这里，我们报告了微管蛋白组装抑制剂噻苯咪唑和2-甲基苯并咪唑在大肠杆菌和蓝藻中引起细胞延长。(C)2000年欧洲微生物学会联合会。爱思唯尔科学公司出版。版权所有。
The bacterial cell division protein FtsZ is a structural analogue of tubulin. Bacterial mutants in which the ftsZ gene is inactivated are unable to divide. Numerous inhibitors of tubulin assembly are known: some of which are used as fungicides. The strong structural homology between FtsZ and tubulin raises the possibility that some of these inhibitors could affect bacterial cell division. Here we report that the tubulin assembly inhibitors thiabendazole and 2-methylbenzimidazole cause cell elongation in Escherichia coli and cyanobacteria. (C) 2000 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.