ENDURANCE TRAINING AFFECTS LACTATE CLEARANCE, NOT LACTATE PRODUCTION
ENDURANCE TRAINING AFFECTS LACTATE CLEARANCE, NOT LACTATE PRODUCTION
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DOI：
10.1152/ajpendo.1983.244.1.e83
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发表时间：
1983-01-01
影响因子：
--
通讯作者：
BROOKS, GA
中科院分区：
文献类型：
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作者：
DONOVAN, CM;BROOKS, GA
使用[2- 3 H]-和[U-14 C]乳酸盐的预充-连续输注研究耐力训练（以29.4 m/min的速度以15%梯度跑步2 h/天）对大鼠乳酸盐代谢的影响。在3种代谢条件下进行测量：休息（Re），轻松运动（EE，13.4 m/min，1%梯度）和剧烈运动（HE，26.8 m/min，1%梯度）。训练动物的血乳酸水平从1.0 . ±. 0.09 mM至1.64 . ±. 0.21在EE和2.66 .+-中。0.38在他。对照组动物也显示出随着工作速率的增加，血乳酸盐增加，但值为1.93 ± 0.01。0.21和4.62 . ±. 0.57分别在EE和HE时为mM。用[U-14 C]乳酸盐测量的乳酸盐周转率（RtLA）从214.0 . ±. 17.0μ mol·cm·kg-1·cm·min-1，在Re中为390.3 ±。31.6在EE和518.1 .+-中。56.4在他。在任何条件下，对照组和经训练的动物之间均未观察到RtLA的显著差异。使用[2- 3 H]乳酸盐获得了RtLA与运动或训练之间的相同关系;获得的值始终比使用[U-14 C]乳酸盐观察到的值高90%。对照组和训练组动物之间的14 C代谢清除率（MCR）在Re方面没有显著差异（180.6 ± 0.01）。27.7 ml·cm·kg-1·cm·min-1）。在EE和HE期间，经过训练的动物的乳酸代谢清除率分别比对照组高37%和107%。耐力训练的效果不是对乳酸产生的影响，而是对乳酸从血液中清除的影响。
Primed-continuous infusion of [2-3H]- and [U-14C]lactate was used to study the effects of endurance training (running 2 h/day at 29.4 m/min up a 15% gradient) on lactate metabolism in rats. Measurements were made under 3 metabolic conditions: rest (Re), easy exercise (EE, 13.4 m/min, 1% gradient) and hard exercise (HE, 26.8 m/min, 1% gradient). Blood lactate levels in trained animals increased from 1.0 .+-. 0.09 mM in Re to 1.64 .+-. 0.21 in EE and 2.66 .+-. 0.38 in HE. Control animals also demonstrated an increase in blood lactate with increasing work rate but values were 1.93 .+-. 0.21 and 4.62 .+-. 0.57 mM at EE and HE, respectively. Lactate turnover rates (RtLA) measured with [U-14C]lactate increased from 214.0 .+-. 17.0 .mu.mol.cntdot.kg-1.cntdot.min-1 in Re to 390.3 .+-. 31.6 in EE and 518.1 .+-. 56.4 in HE. No significant differences in RtLA were observed between controls and trained animals under any condition. Identical relationships between RtLA and exercise or training were obtained with [2-3H]lactate; the values obtained were consistently 90% higher than those observed with [U-14C]lactate. Metabolic clearance rate (MCR) for 14C was not significantly different in Re between control and trained animals (180.6 .+-. 27.7 ml.cntdot.kg-1.cntdot.min-1). Metabolic clearance of lactate in trained animals was 37 and 107% greater than in controls during EE and HE, respectively. Effect of endurance training is not on production of lactate but on its clearance from the blood.