SIMULATION STUDIES OF ELECTROCARDIOGRAM .1. NORMAL HEART
SIMULATION STUDIES OF ELECTROCARDIOGRAM .1. NORMAL HEART
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DOI：
10.1161/01.res.43.2.301
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发表时间：
1978-01-01
影响因子：
20.1
通讯作者：
GESELOWITZ, DB
中科院分区：
文献类型：
--
作者：
MILLER, WT;GESELOWITZ, DB
提出了一种数字计算机模型，用于模拟心室激活和恢复过程中的体表心电图。心脏的脑室由一个由大约4000个点组成的三维阵列详细表示，该阵列被细分为23个区域。从文献中获取的激发序列和细胞动作电位数据被用来确定在模拟的心动周期中的每个时刻的细胞内电位的空间分布。代表每个区域的单个偶极子的矩是通过对整个区域的细胞内电位分布的空间梯度求和来确定的。然后用得到的23个偶极子的集合来计算成人躯干形状的有界均匀体积导体表面的电势。模拟的激活和恢复过程中的等电势表面图与文献中报道的人类数据很好地吻合。
A digital computer model is presented for the simulation of the body surface electrocardiogram (ECG) during ventricular activation and recovery. The ventricles of the heart are represented in detail by a three-dimensional array of approximately 4000 points which is subdivided into 23 regions. Excitation sequence and cellular action potential data taken from the literature are used to determine the spatial distribution of intracellular potentials at each instant of time during a simulated cardiac cycle. The moment of the single dipole representing each region is determined by summing the spatial gradient of the intracellular potential distribution throughout the region. The resulting set of 23 dipoles is then used to calculate the potentials on the surface of a bounded homogeneous volume conductor with the shape of an adult torso. Simulated isopotential surface maps during both activation and recovery are in good agreement with data for humans reported in the literature.