Synthesis and characterization of novel iron-specific bicyclic fluorescent probes
Synthesis and characterization of novel iron-specific bicyclic fluorescent probes
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新型铁特异性双环荧光探针的合成和表征
DOI：
10.1016/j.snb.2015.02.072
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Ma Y
中科院分区：
文献类型：
--
作者：
Ma Y
合成了10种新的铁特异性荧光探针，其中荧光部分与分子的螯合实体合并。这些化合物已被开发，以取代传统的荧光探针的细胞内不稳定的铁池的定量。已经进行了铁以及其他金属对探针的影响的评估。配体较低的pKa值是由于6位氨基的诱导作用。由于与质子的竞争减少，pFe 3+值相应增加。这些配体紧密地螯合铁。
The synthesis of 10 novel iron-specific fluorescent probes is described, where the fluorescent moiety is merged with chelating entity of the molecule. These compounds have been developed in order to replace the traditional fluorescent probes for the quantification of intracellular labile iron pools. An evaluation of the effect of iron as well as other metals on the probes has been undertaken. The relatively low pKavalues of the ligands result from an inductive effect of the amido group at 6-position. As a result of the decreased competition with protons, the pFe3+values are correspondingly increased. These ligands chelate iron tightly.