Birth rate among patients with epilepsy:: A nationwide population-based cohort study in finland
Birth rate among patients with epilepsy:: A nationwide population-based cohort study in finland
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DOI：
10.1093/aje/kwh140
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发表时间：
2004-06-01
影响因子：
5
通讯作者：
Auvinen, A
中科院分区：
文献类型：
--
作者：
Artama, M;Isojärvi, JIT;Auvinen, A
关于癫痫患者出生率的基于人群的研究报告很少。在以前的大多数研究中，癫痫患者的生育率低于其他人群。然而，也有相互矛盾的结果。由于小样本和选择性材料，这些结果的普遍性也是有限的。作者在芬兰全国范围内的新诊断癫痫患者队列和基于人群的参考队列中进行了一项基于人群的出生率队列研究（1985-2001年）。从芬兰社会保险机构（KELA）数据库中确定了1985年至1994年期间首次批准符合抗癫痫药物报销条件的所有患者（n= 14，077）。从芬兰人口登记中心确定了一个参考队列（n= 29，828），年龄频率匹配。还从芬兰人口登记中心获得了关于随访状态和活产的信息。男性（风险比=0.58，95%置信区间：0.54，0.62）和女性（风险比=0.88，95%置信区间：0.83，0.93）癫痫患者的出生率均低于参考队列。在男性癫痫患者中，观察时年龄呈明显下降趋势，在女性癫痫患者中，随访开始时年龄呈中度下降趋势。
Few reports on population-based studies of birth rate among epilepsy patients have been published. In most previous studies, fertility has been lower among epilepsy patients than in the rest of the population. However, conflicting results have also been reported. Because of small samples and selective material, the generalizability of these results is also limited. The authors conducted a population-based cohort study of birth rate (1985-2001) in a nationwide Finnish cohort of patients with newly diagnosed epilepsy and a population-based reference cohort. All patients (n=14,077) approved as eligible for reimbursement for antiepileptic medication from the Social Insurance Institution of Finland (KELA) for the first time between 1985 and 1994 were identified from the KELA database. A reference cohort (n=29,828) was identified from the Finnish Population Register Center, with frequency-matching on age. Information on follow-up status and livebirths were also obtained from the Finnish Population Register Center. The birth rate was lower in patients with epilepsy than in the reference cohort among both men (hazard ratio=0.58, 95% confidence interval: 0.54, 0.62) and women (hazard ratio=0.88, 95% confidence interval: 0.83, 0.93). There were a clear decreasing trend by age at observation in men with epilepsy and a moderate decreasing trend by age at start of follow-up in women with epilepsy.