A Thermodynamic Analysis of Three-Phase Equilibria in Binary and Ternary Systems for Applications in Rapid Expansion of a Supercritical Solution (RESS), Particles from Gas-Saturated Solutions (PGSS), and Supercritical Antisolvent (SAS)
A Thermodynamic Analysis of Three-Phase Equilibria in Binary and Ternary Systems for Applications in Rapid Expansion of a Supercritical Solution (RESS), Particles from Gas-Saturated Solutions (PGSS), and Supercritical Antisolvent (SAS)
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DOI：
10.1021/ie970376u
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发表时间：
1997-12
影响因子：
4.2
通讯作者：
Ireneo Kikic and;M. Lora;A. Bertucco
中科院分区：
文献类型：
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作者：
Ireneo Kikic and;M. Lora;A. Bertucco
超临界流体正越来越多地用作微细颗粒形成的介质：最重要的技术是超临界溶液过程（RESS）的快速膨胀、来自气体饱和溶液过程（PGSS）的颗粒和超临界抗溶剂重结晶过程（SAS）。为了验证这种过程的可行性，并优化操作变量的选择，重要的是要了解所涉及的系统的相行为。为了进行热力学分析，必须使用状态方程来考虑压力的影响;此外，还涉及固相，并且重组分通常是高分子量且表征较差的化合物。在这项工作中，Peng-罗宾逊状态方程与经典的混合规则和一个或两个二元相互作用参数。固相中重组分的逸度是通过过冷液体参考状态计算的：只有熔化热和熔化滕佩。
Supercritical fluids are being increasingly used as media for fine particles formation: the most important techniques are the rapid expansion of a supercritical solution process (RESS), the particles from gas-saturated solutions process (PGSS), and the supercritical antisolvent recrystallization process (SAS). To verify the feasibility of such processes, and to optimize the choice of operative variables, it is important to understand the phase behavior of the systems involved. To perform a thermodynamic analysis, an equation of state has to be used to take into account the effects of pressure; moreover, a solid phase is involved, and the heavy component is usually a high molecular weight and poorly characterized compound. In this work the Peng−Robinson equation of state with classical mixing rules and one or two binary interaction parameters are used. The fugacity of the heavy component in the solid phase is calculated by means of a subcooled liquid reference state: only heat of fusion and melting tempe...