Sensitizing and toxicity properties of misonidazole and its derivatives.
Sensitizing and toxicity properties of misonidazole and its derivatives.
复制标题
米索硝唑及其衍生物的致敏和毒性特性。
DOI：
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发表时间：
1978
期刊：
影响因子：
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通讯作者：
A. J. Varghese
中科院分区：
文献类型：
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作者：
G. Whitmore;S. Gulyás;A. J. Varghese
在对低氧细胞特异性的辐射增敏剂的早期研究中，人们希望这样的化合物将模拟氧的许多关键特征，它们将产生剂量改变类型的辐射增敏，对需氧细胞没有影响，代谢缓慢并且无毒。我们最近对米索硝唑的研究表明，在某些条件下，它确实产生对低氧细胞特异性的剂量调节作用，但在更长时间暴露的条件下，低氧细胞产生该化合物的衍生物，其中至少一种将减少有氧和有氧代谢的肩。
IN the early search for radiation sensitizers specific for hypoxic cells it was hoped that such compounds would mimic a number of critical features of oxygen, that they would produce a dose modification type of radiation sensitization, be without effect on aerobic cells, be slowly metabolized and would be non-toxic. Our most recent studies with misonidazole indicate that under certain conditions it does produce a dose-modifying effect specific for hypoxic cells, but that under conditions of more prolonged exposure hypoxic cells produce derivatives of the compound, at least one of which will reduce the shoulder of both aerobic and