Diffusion tensor imaging for preoperative evaluation of tumor grade in gliomas
Diffusion tensor imaging for preoperative evaluation of tumor grade in gliomas
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DOI：
10.1016/j.clineuro.2004.06.011
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发表时间：
2005-04-01
影响因子：
1.9
通讯作者：
Kabasawa, H
中科院分区：
文献类型：
--
作者：
Inoue, T;Ogasawara, K;Kabasawa, H
本文应用3.0T磁共振扩散张量成像（DTI）技术对41例经病理证实的胶质瘤进行了水扩散参数的测量，并对结果进行了分析。计算各向异性分数（FA）和平均扩散率（MD），并与WHO胶质瘤分级进行比较，1级胶质瘤FA值（0.150 ± 0.017）显著低于3级（0.23 ± 0.033）和4级（0.229 ± 0.033）（P < 0.0001）。2级胶质瘤的FA值（0.159 ± 0.018）显著低于3级和4级胶质瘤（P = 0.0002，P < 0.0001）。低级别和高级别胶质瘤之间的FA阈值为0.188。1级胶质瘤的MD值（1619.1 +/- 157.4 x 10（-6）mm（2）/s）显著高于3级（1084.5 +/- 218.9 x 10（-6）mm（2）/s）（P = 0.0036）或4级胶质瘤（1098.0 +/- 291.6 x 10（-6）mm（2）/s）（P = 0.0002）。MD值与胶质瘤的其他分级无关，FA值可区分高、低级别胶质瘤。这对决定手术策略或选择立体定向活检部位是有用的。(c)2004 Elsevier B. V.保留所有权利。
The relationship between water diffusion parameters measured using diffusion tensor imaging (DTI) and histological malignancy of gliomas was investigated.DTI was performed using a 3.0 T MR scanner in 41 consecutive patients with histologically proven gliomas. Fractional anisotropy (FA) and mean diffusivity (MD) were calculated and compared with the WHO classification of the gliomas.The FA values of grade 1 gliomas (0.150 +/- 0.017) were significantly lower than those of grade 3 (0.23 +/- 0.033) or grade 4 gliomas (0.229 +/- 0.033) (P < 0.0001, respectively). The FA values of grade 2 gliomas (0.159 +/- 0.018) were significantly lower than those of grade 3 or grade 4 gliomas (P = 0.0002, P < 0.0001, respectively). The FA threshold between low grade and high grade gliomas was 0.188. The MD values of grade 1 gliomas (1619.1 +/- 157.4 x 10(-6) mm(2)/s) were significantly higher than those of grade 3 (1084.5 +/- 218.9 x 10(-6) mm(2)/s) (P = 0.0036) or grade 4 gliomas (1098.0 +/- 291.6 x 10(-6) mm(2)/s) (P = 0.0002). The MD values were not correlated with the other grades of glioma.FA values can distinguish between high grade and low grade gliomas. This is useful in deciding the surgical strategy or selecting the site of stereotactic biopsy. (c) 2004 Elsevier B.V. All rights reserved.