Perspectives series: host/pathogen interactions. Apoptosis in bacterial pathogenesis.
Perspectives series: host/pathogen interactions. Apoptosis in bacterial pathogenesis.
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DOI：
10.1172/jci119557
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发表时间：
1997-08
期刊：
影响因子：
--
通讯作者：
A. Zychlinsky;P. Sansonetti
中科院分区：
文献类型：
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作者：
A. Zychlinsky;P. Sansonetti
越来越多的细菌病原体在体外被确定为细胞凋亡的媒介(1，2)。这些病原体感染许多不同的组织，包括革兰氏阳性和阴性细菌以及分枝杆菌。在这篇综述中，我们分析了细胞凋亡在细菌发病中的作用。至少有三种致病策略涉及程序性细胞死亡：激活细胞凋亡以破坏细胞，利用细胞凋亡来启动炎症(3)，以及抑制宿主细胞的凋亡。此外，宿主细胞的凋亡可能代表了宿主防御反应(4)。
Increasing numbers of bacterial pathogens have been identified as mediators of apoptosis in vitro (1, 2). These pathogens infect many different tissues and include gram-positive and -negative bacteria as well as Mycobacteria . In this review, we analyze the role of apoptosis in bacterial pathogenesis. At least three pathogenic strategies involve programmed cell death: activation of apoptosis to destroy cells, utilization of apoptosis to initiate inflammation (3), and inhibition of host cell apoptosis. In addition, host cell apoptosis might represent a host defense reaction (4).