Disorders of reproduction in patients with epilepsy: Primary neurological mechanisms
Disorders of reproduction in patients with epilepsy: Primary neurological mechanisms
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DOI：
10.1016/j.seizure.2007.11.025
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发表时间：
2008-03-01
影响因子：
3
通讯作者：
Herzog, Andrew G.
中科院分区：
文献类型：
--
作者：
Herzog, Andrew G.
生殖障碍在女性和男性癫痫患者中异常常见。它们通常与生殖内分泌失调有关，也可能是生殖内分泌失调的后果。癫痫本身和抗癫痫药物的使用都与其病理生理学有关。本文综述了癫痫患者颞缘功能障碍如何影响正常的神经内分泌调节，促进生殖内分泌紊乱的发展。调节异常的特殊性质可能与癫痫的偏侧性和局灶性有关，并且某些激素变化可能与癫痫样放电的发生密切相关。女性生殖内分泌紊乱包括多囊卵巢综合征、下丘脑性闭经、功能性高泌乳素血症和过早绝经。在男性中，性腺功能减退症可能是低促性腺激素、高促性腺激素或与高催乳素血症有关。这些生殖内分泌紊乱的重要性在于，它们不仅可能导致性功能障碍和不育，而且可能对癫痫控制产生不利影响。(C)2007年英国癫痫协会。由Else vier Ltd.出版。保留所有权利。
Reproductive disorders are unusually common among women and men with epilepsy. They are generally associated with and may be the consequence of reproductive endocrine disorders. Both epilepsy itself and antiepileptic drug use have been implicated in their pathophysiology. This review focuses on how temporolimbic dysfunction in epilepsy may disrupt normal neuroendocrine regulation and promote the development of reproductive endocrine disorders. The particular nature of the dysregulation may relate to the laterality and focality of the epilepsy and some hormonal changes may develop in close temporal relation to the occurrence of epileptiform discharges. In women, reproductive endocrine disorders include polycystic ovary syndrome, hypothalamic amenorrhea, functional hyperprolactinemia, and premature menopause. In men, hypogonadism may be hypogonadotropic, hypergonadotropic or related to hyperprolactinemia. The significance of these reproductive endocrine disorders is that they may contribute not only to sexual dysfunction and infertility but may also have an adverse impact on seizure control. (C) 2007 British Epilepsy Association. Published by Else vier Ltd. All rights reserved.