Neural pathways in medial septal cholinergic modulation of chronic pain: distinct contribution of the anterior cingulate cortex and ventral hippocampus
Neural pathways in medial septal cholinergic modulation of chronic pain: distinct contribution of the anterior cingulate cortex and ventral hippocampus
复制标题
慢性疼痛内侧间隔胆碱能调节的神经通路：前扣带皮层和腹侧海马的独特贡献
DOI：
10.1097/j.pain.0000000000001240
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发表时间：
2018-08-01
期刊：
影响因子：
7.4
通讯作者：
Yi, Ming
中科院分区：
文献类型：
--
作者：
Jiang, Ying-Ying;Shao, Shan;Yi, Ming
摘要一种特定的行为可以通过不同的神经通路协同调节。内侧隔（MS）胆碱能系统支配广泛的皮质和皮质下区域，并参与疼痛调制，但其潜在的神经通路尚未完全了解。本研究探讨了MS胆碱能神经元和2个神经通路：MS-喙前扣带皮层（rACC）和MS-腹侧海马CA 1（vCA 1），在调节慢性炎症性疼痛小鼠模型的感知和情感疼痛行为的贡献。我们发现，慢性疼痛激活MS胆碱能神经元和锥体神经元的rACC，但抑制锥体神经元的活动，在vCA 1，所有这些都有助于维持病理性疼痛。MS胆碱能神经元或MS-rACC通路的化学发生抑制抑制rACC锥体神经元的活动和衰减慢性疼痛的感知和情感维度。相比之下，MS胆碱能神经元的化学激活也产生镇痛，但通过拯救vCA 1中功能减退的锥体神经元。这些结果清楚地表明，MS胆碱能系统通过MS-rACC或MS-vCA 1通路差异调节慢性炎性疼痛。更重要的是，我们的研究提供了一个新的范例的神经回路调制的证据：MS胆碱能抑制和激活诱导类似的镇痛，但通过不同的神经通路。
Abstract One specific behavior can be synergistically modulated by different neural pathways. Medial septal (MS) cholinergic system innervates widespread cortical and subcortical regions and participates in pain modulation, but the underlying neural pathways are not fully understood. This study examined the contribution of MS cholinergic neurons and 2 neural pathways: MS–rostral anterior cingulate cortex (rACC) and MS–ventral hippocampal CA1 (vCA1), in modulating perceptual and affective pain behaviors in a mouse model of chronic inflammatory pain. We found that chronic pain activated MS cholinergic neurons and pyramidal neurons in the rACC, but suppressed pyramidal neuronal activities in the vCA1, all of which contributed to the maintenance of pathological pain. Chemogenetic inhibition of MS cholinergic neurons or the MS–rACC pathway inhibited rACC pyramidal neuronal activities and attenuated perceptual and affective dimensions of chronic pain. By contrast, chemogenetic activation of MS cholinergic neurons also produced analgesia, but by rescuing hypofunctional pyramidal neurons in vCA1. These results clearly demonstrate that the MS cholinergic system differentially modulates chronic inflammatory pain through MS–rACC or MS–vCA1 pathways. More significantly, our research provides evidence for a novel paradigm of neural circuit modulation: MS cholinergic inhibition and activation induce similar analgesia but through distinct neural pathways.