Role of HLA Allele Polymorphism in Chronic Hepatitis B Virus Infection and HBV Vaccine Sensitivity in Patients from Eastern Turkey
Role of HLA Allele Polymorphism in Chronic Hepatitis B Virus Infection and HBV Vaccine Sensitivity in Patients from Eastern Turkey
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DOI：
10.1007/s10528-010-9404-6
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发表时间：
2011-04-01
影响因子：
2.4
通讯作者：
Pirim, Ibrahim
中科院分区：
文献类型：
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作者：
Albayrak, Ayse;Ertek, Mustafa;Pirim, Ibrahim
人类白细胞抗原（HLA）等位基因与B肝炎病毒（HBV）感染的临床结局相关，其范围从自发恢复到肝细胞癌。在这项涉及土耳其东部受试者的研究中，慢性HBV组中HLA-B35、HLA-CW 4、HLA-DQ 2和HLA-DQ 8的频率明显高于自发恢复组，无应答HBV疫苗组中HLA-A11和HLA-A24的频率明显高于应答HBV疫苗组;免疫无应答组HLA-CW 6频率明显低于免疫应答组。对与慢性HBV感染进展相关的HLA类型及其在分子水平上对细胞的影响的全面了解将对开发新的HBV疫苗和慢性HBV感染的新治疗策略做出重要贡献。
Human leukocyte antigen (HLA) alleles have been associated with the clinical outcomes of hepatitis B virus (HBV) infection, which range from spontaneous recovery to hepatocellular carcinoma. In this study involving subjects from eastern Turkey, the frequencies of HLA-B35, HLA-CW4, HLA-DQ2, and HLA-DQ8 were markedly higher in the chronic HBV group than those in the spontaneously recovered group; the frequencies of HLA-A11 and HLA-A24 in the nonresponsive HBV vaccine group were markedly higher than those in the responsive HBV vaccine group; and the frequency of HLA-CW6 in the nonresponsive HBV vaccine group was significantly lower than in the responsive group. A complete understanding of HLA types associated with the progression to chronic HBV infection and their effects within the cell at the molecular level will be an important contribution in the development of new HBV vaccines and new treatment strategies for chronic HBV infection.