Effects of interstitial irradiation alone, or in combination with localized hyperthermia on the response of a mouse mammary tumor.
Effects of interstitial irradiation alone, or in combination with localized hyperthermia on the response of a mouse mammary tumor.
复制标题
单独间质照射或与局部热疗组合对小鼠乳腺肿瘤反应的影响。
DOI：
10.1269/jrr.19.175
复制
发表时间：
1978
影响因子：
2
通讯作者：
E. Gerner
中科院分区：
文献类型：
--
作者：
R. Miller;J. Leith;R. Veomett;E. Gerner
评估了 226Ra 间质照射和局部热疗（单独或组合）对小鼠可移植性乳腺肉瘤 (EMT6) 生长的影响。肿瘤对联合治疗的反应表明这两种药物之间存在相互作用。局部热疗（43°C，1小时）与间质照射相结合，连续治疗4天后，肿瘤体积减少了60%以上，而单独使用任一药物时，肿瘤体积仅减少了20%。这些数据表明，这种联合治疗可能对目前使用间质放射治疗的某些局部人类癌症有益。
Assessment has been made on the effects of interstitial irradiation from 226Ra and localized hyperthermia, either alone or in combination, on the growth of a transplantable mammary sarcoma (EMT6) in the mouse. Tumor responses to the combined treatments indicated a maked interaction of these two agents. Localized hyperthermia (43°Celsius, 1 hr) combined with interstitial irradiation led to greater than a 60 percent reduction in tumor volume after 4 days of continuous treatment, compared to only a 20 percent reduction in tumor volume when either agent was given alone. These data suggest that such combined treatment may be of benefit in certain localized human cancers in which interstitial radiation treatment is in current use.