Synthesis and evaluation of compounds that induce readthrough of premature termination codons.
Synthesis and evaluation of compounds that induce readthrough of premature termination codons.
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诱导提前终止密码子通读的化合物的合成和评估。
DOI：
10.1016/j.bmcl.2011.07.107
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发表时间：
2011
影响因子：
2.7
通讯作者：
Gatti,RichardA
中科院分区：
文献类型：
--
作者：
Jung,MichaelE;Ku,Jin-Mo;Du,Liutao;Hu,Hailiang;Gatti,RichardA
进行了构效关系（SAR）研究，以确定诱导提前终止密码子通读的新型小分子量化合物。特别是，评估了 RTC13, 1 的类似物。此外，假设这些化合物通过与核糖体结合而发挥其活性，我们制备了含有嘧啶碱基的杂合类似物13，它们也表现出良好的通读活性。
A structure–activity relationship (SAR) study was carried out to identify novel, small molecular weight compounds which induce readthrough of premature termination codons. In particular, analogs of RTC13, 1, were evaluated. In addition, hypothesizing that these compounds exhibit their activity by binding to the ribosome, we prepared the hybrid analogs 13 containing pyrimidine bases and these also showed good readthrough activity.