Epidemiology of idiosyncratic drug-induced liver injury.
Epidemiology of idiosyncratic drug-induced liver injury.
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DOI：
10.1055/s-0029-1240002
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发表时间：
2009-11
影响因子：
4.2
通讯作者：
Chalasani N
中科院分区：
文献类型：
--
作者：
Bell LN;Chalasani N
特异性药物性肝损伤(DILI)是一个重大的健康问题，因为它的性质不可预测，对其发病机制知之甚少，并有可能导致致命后果。这也是药物开发和安全处方药营销的一个重大障碍。特殊的帝力病一般很少见，但由于缺乏积极的报告或监测系统，以及在识别和诊断过程中涉及的重大挑战，它的发生可能被低估。尽管如此，在儿童和成人中，DILI是潜在严重和致命的急性肝功能衰竭的常见原因。准确估计DILI发病率和全谱的基于人群的研究有限。然而，根据一项以人口为基础的法国前瞻性研究，估计每年每10万居民中有13.9±2.4例DILI病例，据此推断，美国每年将有近44,000人患有DILI。虽然由于草药和膳食补充剂，越来越多的患者也出现了DILI，但这一实体的流行病学需要进一步调查。本文对DILI在普通人群和潜在高危人群中的流行病学进行了综述。
Idiosyncratic drug-induced liver injury (DILI) is a significant health problem because of its unpredictable nature, poorly understood pathogenesis, and potential to cause fatal outcomes. It is also a significant hurdle for drug development and marketing of safe prescription medications. Idiosyncratic DILI is generally rare, but its occurrence is likely underappreciated due to the lack of active reporting or surveillance systems and substantial challenges involved in its recognition and diagnosis. Nonetheless, DILI is a common cause of potentially serious and fatal acute liver failure in both children and adults. Population-based studies that accurately estimate the incidence and full spectrum of DILI are limited. However, using a prospective, population-based French study with an annual estimated incidence of 13.9 ± 2.4 DILI cases per 100,000 inhabitants, it has been extrapolated that nearly 44,000 individuals in the United States will suffer from DILI each year. Although increasing numbers of patients are also being seen with DILI due to herbal and dietary supplements, the epidemiology of this entity requires further investigation. In this article, the epidemiology of DILI, both in the general population and in potentially high-risk subgroups, is reviewed.
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