p53: emerging roles in stem cells, development and beyond
p53: emerging roles in stem cells, development and beyond
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DOI：
10.1242/dev.158360
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发表时间：
2018-04-15
期刊：
影响因子：
4.6
通讯作者：
Barton, Michelle Craig
中科院分区：
文献类型：
--
作者：
Jain, Abhinav K.;Barton, Michelle Craig
大多数人类癌症在编码p53的基因中含有突变。因此，在过去的几十年里，对p53的研究主要集中在其作为肿瘤抑制因子的作用上。这种关注的一个后果是，p53在发育中的功能在很大程度上被忽视了。然而，最近的进展，如胚胎干细胞的基因组分析，揭示了p53在哺乳动物细胞分化和发育中的作用和机制。正如我们在这里回顾，这些最近的研究结果揭示了作用，补充了肿瘤抑制中p53的既定作用。
Most human cancers harbor mutations in the gene encoding p53. As a result, research on p53 in the past few decades has focused primarily on its role as a tumor suppressor. One consequence of this focus is that the functions of p53 in development have largely been ignored. However, recent advances, such as the genomic profiling of embryonic stem cells, have uncovered the significance and mechanisms of p53 functions in mammalian cell differentiation and development. As we review here, these recent findings reveal roles that complement the well-established roles for p53 in tumor suppression.