Neurobiology of rodent self-grooming and its value for translational neuroscience.
Neurobiology of rodent self-grooming and its value for translational neuroscience.
复制标题
DOI：
10.1038/nrn.2015.8
复制
发表时间：
2016-01
期刊：
影响因子：
--
通讯作者：
Fentress JC
中科院分区：
文献类型：
--
作者：
Kalueff AV;Stewart AM;Song C;Berridge KC;Graybiel AM;Fentress JC
自我理毛是一种复杂的先天行为，具有进化保守的序列模式，是啮齿动物最常见的行为活动之一。在这篇综述中，我们讨论了啮齿动物自我梳理的神经生物学，我们强调了神经精神疾病的啮齿动物模型的研究-包括自闭症谱系障碍和强迫症的模型-已经评估了自我梳理表型。我们认为，啮齿类动物的自我梳理可能是一个有用的措施，在这种模式中的重复行为，因此，价值的转化精神病学。啮齿动物自我梳理的评估也可能有助于了解参与复杂的顺序动作模式的神经回路。
Self-grooming is a complex innate behaviour with an evolutionary conserved sequencing pattern and is one of the most frequently performed behavioural activities in rodents. In this Review, we discuss the neurobiology of rodent self-grooming, and we highlight studies of rodent models of neuropsychiatric disorders — including models of autism spectrum disorder and obsessive compulsive disorder — that have assessed self-grooming phenotypes. We suggest that rodent self-grooming may be a useful measure of repetitive behaviour in such models, and therefore of value to translational psychiatry. Assessment of rodent self-grooming may also be useful for understanding the neural circuits that are involved in complex sequential patterns of action.