Relatively High Prevalence of Drug Resistance Among Antiretroviral-Naive Patients from Henan, Central China
Relatively High Prevalence of Drug Resistance Among Antiretroviral-Naive Patients from Henan, Central China
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DOI：
10.1089/aid.2013.0144
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发表时间：
2014-02-01
影响因子：
1.5
通讯作者：
Yang, Rongge
中科院分区：
文献类型：
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作者：
Li, Lingnuo;Sun, Binlian;Yang, Rongge
为了阐明河南省HIV-1亚型的流行情况和传播的耐药性，我们从2009年8月至2010年11月收集了187例抗逆转录病毒初治患者的HIV-1阳性血液样本。B亚型（92.0%，172/187）仍然是河南省HIV-1的主要亚型，在所有危险人群和地理区域中流行。在98个pol序列中，67个（68.4%）含有耐药突变，只有14个（14.3%，14/98）序列具有与抗逆转录病毒药物表型敏感性显著降低相关的突变。河南省的耐药率出乎意料地高，主要是由于蛋白酶和整合酶区域的微小突变的流行，特别是A71 T/V和L 68 V/I/IM/LV。总之，我们在河南省抗逆转录病毒初治患者中发现了相对较高的耐药率和独特的突变分布。
To elucidate the prevalence of HIV-1 subtypes and transmitted drug resistance in Henan, central China, HIV-1-positive blood samples from 187 antiretroviral-naive patients were collected in our study from August 2009 to November 2010. Subtype B (92.0%, 172 of 187) remains the predominant HIV-1 subtype in Henan province and was prevalent in all risk populations and geographic regions. Of 98 pol sequences 67 (68.4%) harbored drug resistance mutations, and only 14 (14.3%, 14 of 98) sequences have mutations associated with significantly reduced phenotypic susceptibility to antiretroviral drugs. The unexpectedly high percentage of drug resistance in Henan province is mainly due to the prevalence of minor mutations in the protease and integrase regions, especially A71T/V and L68V/I/IM/LV. In all, we detected a relatively high prevalence of drug resistance with unique mutation distributions among antiretroviral-naive patients from Henan province.